Description

(S)-5-Fluoro-3-Methylisobenzofuran-1(3H)-One is a high-value chiral building block and pharmaceutical intermediate. This compound is critical for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs) and advanced materials, where its specific stereochemistry and fluorinated isobenzofuranone core impart unique biological and physicochemical properties. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel therapeutic agents and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel small-molecule drugs, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced, enantiomerically pure pesticides and herbicides with improved efficacy and environmental profiles.
• Asymmetric Catalysis: Serves as a precursor or ligand in asymmetric synthesis to construct complex molecular architectures with high stereoselectivity.
• Material Science Research: Employed in the development of specialty polymers and advanced organic materials with tailored optical or electronic properties.
• Process Chemistry & Scale-up: Used in pilot plants and commercial manufacturing for the production of target APIs under current Good Manufacturing Practice (cGMP) standards.
• Academic & Contract Research: A valuable reagent for medicinal chemistry programs and custom synthesis projects in academic and contract research organizations (CROs).

Basic Information

Product Name	(S)-5-Fluoro-3-Methylisobenzofuran-1(3H)-One
CAS No.	1803573-19-4
Molecular Formula	C9H7FO2
Molecular Weight	166.15 g/mol
Synonyms	(3S)-5-Fluoro-3-methyl-1,3-dihydro-2-benzofuran-1-one; (S)-5-Fluoro-3-methylisobenzofuran-1-one; (S)-5-Fluoro-3-methylphthalide; (S)-5-Fluoro-3-methyl-1(3H)-isobenzofuranone; (S)-5-Fluoro-3-methyl-2-benzofuran-1(3H)-one; (S)-5-Fluoro-3-methyl-1,3-dihydroisobenzofuran-1-one; (S)-5-Fluoro-3-methyl-3H-isobenzofuran-1-one
EINECS	Contact for details

Quality Control

Our (S)-5-Fluoro-3-Methylisobenzofuran-1(3H)-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/GC) are provided for every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). For long-term storage under an inert atmosphere (e.g., nitrogen or argon) is recommended to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.