Description

3-Chloro-5-(Trifluoromethoxy)Phenylboronic Acid, Pinacol Ester is a high-purity, synthetically valuable organoboron reagent, specifically a protected boronic acid derivative. This compound is essential for enabling efficient and selective cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are fundamental to modern pharmaceutical and advanced materials research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for constructing drug candidates containing the 3-chloro-5-(trifluoromethoxy)phenyl moiety, particularly in CNS and anti-inflammatory research.
• Agrochemical Active Ingredient Development: Used in the synthesis of novel herbicides and fungicides, leveraging the stability and reactivity of the pinacol boronic ester.
• Material Science & OLED Research: Serves as a precursor for creating functionalized organic molecules used in electronic materials, liquid crystals, and organic light-emitting diodes (OLEDs).
• Suzuki-Miyaura Cross-Coupling Reactions: The primary application, enabling the formation of carbon-carbon bonds between aryl halides and this boronic ester under palladium catalysis.
• Parallel & Combinatorial Chemistry: Ideal for library synthesis due to its stability compared to the free boronic acid, allowing for longer shelf-life and simplified handling in high-throughput screening.
• Ligand & Catalyst Development: Used to synthesize novel chelating ligands or functionalized catalysts for asymmetric synthesis and other catalytic processes.

Basic Information

Product Name	3-Chloro-5-(Trifluoromethoxy)Phenylboronic Acid, Pinacol Ester
CAS No.	1803320-97-9
Molecular Formula	C₁₃H₁₅BClF₃O₃
Molecular Weight	322.51 g/mol
Synonyms	3-Chloro-5-(trifluoromethoxy)benzeneboronic acid pinacol ester; 2-[3-Chloro-5-(trifluoromethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (3-Chloro-5-(trifluoromethoxy)phenyl)boronic acid pinacol ester; 3-Chloro-5-(trifluoromethoxy)phenylboronic acid pinacol ester; 3-Chloro-5-(trifluoromethoxy)phenyl-Bpin; B-[3-Chloro-5-(trifluoromethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 3-Chloro-5-(Trifluoromethoxy)Phenylboronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is light-sensitive (store away from light). Keep the container tightly sealed under an inert atmosphere to maximize long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Assay (NMR)	≥95.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.