Description

2-Propanesulfinamide, n-[(1S)-1-[2-[[(1,1-Dimethylethyl)Diphenylsilyl]Oxy]Phenyl]-2-(Diphenylphosphino)Ethyl]-2-Methyl-, [S(R)]- is a sophisticated chiral organosulfur and phosphine-containing ligand, designed for high-precision asymmetric synthesis. This compound is a critical reagent for constructing complex molecular architectures with exceptional stereochemical control, enabling the production of enantiomerically pure intermediates. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and advanced materials sectors for catalytic cross-coupling and nucleophilic addition reactions.

Application

• Asymmetric Catalysis: Serves as a key chiral ligand in transition metal-catalyzed reactions, such as asymmetric hydrogenation and cross-coupling, for the synthesis of active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate Synthesis: Enables the stereoselective formation of carbon-carbon and carbon-heteroatom bonds in the multi-step synthesis of complex drug candidates.
• Methodology Development: Used in academic and industrial R&D laboratories to develop new catalytic protocols for enantioselective synthesis.
• Ligand Screening Libraries: A valuable component in high-throughput screening for identifying optimal catalyst systems for challenging transformations.
• Fine Chemical Production: Applied in the pilot and commercial-scale manufacture of specialty chemicals requiring high enantiomeric purity.

Basic Information

Product Name	2-Propanesulfinamide, n-[(1S)-1-[2-[[(1,1-Dimethylethyl)Diphenylsilyl]Oxy]Phenyl]-2-(Diphenylphosphino)Ethyl]-2-Methyl-, [S(R)]-
CAS No.	1803239-59-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(S)-tert-Butyl(2-((S)-2-(Diphenylphosphino)-1-((R)-2-Methylpropane-2-Sulfinamido)Ethyl)Phenoxy)Diphenylsilane; Chiral Sulfinamide-Phosphine Hybrid Ligand; N-[(1S)-1-[2-[(tert-Butyldiphenylsilyl)Oxy]Phenyl]-2-(Diphenylphosphino)Ethyl]-2-Methyl-2-Propanesulfinamide, [S(R)]-; Asymmetric Bifunctional Ligand; TBDPS-Protected Chiral Auxiliary Ligand; CAS 1803239-59-9
EINECS	Contact for details

Quality Control

Every batch of this high-value chiral ligand is produced and analyzed under strict quality management protocols to ensure consistency and performance. Identity and purity are confirmed via advanced analytical techniques including HPLC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and other critical parameters is provided with each shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place (recommended 2-8°C or as specified on the label) to maintain stability. This material is moisture-sensitive and easily oxidized; ensure containers are sealed immediately after use to minimize exposure to air and humidity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.