Description

2-Propanesulfinamide, n-[(1R)-1-[2-[[(1,1-Dimethylethyl)Diphenylsilyl]Oxy]Phenyl]-2-(Diphenylphosphino)Ethyl]-2-Methyl-, [S(R)]- is a sophisticated chiral organocatalyst and ligand, pivotal for enabling highly selective and efficient asymmetric synthesis. Its complex structure, featuring both sulfinamide and phosphine moieties, provides a unique three-dimensional environment for controlling stereochemistry in critical bond-forming reactions. This compound is essential for research chemists and process development scientists in the pharmaceutical and fine chemical industries who require high-purity, specialized catalysts to synthesize enantiomerically pure active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• As a chiral ligand in transition metal-catalyzed asymmetric reactions, including hydrogenation and cross-coupling.
• As an organocatalyst for the enantioselective synthesis of complex molecules in medicinal chemistry research.
• In the development and scale-up of stereoselective synthetic routes for novel pharmaceutical candidates.
• For the preparation of high-value chiral building blocks and advanced intermediates in fine chemical production.
• As a key reagent in academic and industrial research focused on new methodologies in asymmetric catalysis.

Basic Information

Product Name	2-Propanesulfinamide, n-[(1R)-1-[2-[[(1,1-Dimethylethyl)Diphenylsilyl]Oxy]Phenyl]-2-(Diphenylphosphino)Ethyl]-2-Methyl-, [S(R)]-
CAS No.	1803239-58-8
Molecular Formula	C40H44NO2PSSi
Molecular Weight	653.92 g/mol
Synonyms	(SR)-N-[(1R)-1-[2-[(tert-Butyldiphenylsilyl)oxy]phenyl]-2-(diphenylphosphino)ethyl]-2-methylpropane-2-sulfinamide; (S)-tert-Butanesulfinamide, N-[(1R)-1-[2-[(tert-butyldiphenylsilyl)oxy]phenyl]-2-(diphenylphosphino)ethyl]-2-methyl-; Chiral Sulfinamide-Phosphine Hybrid Ligand; TBDPS-Protected Chiral Sulfinamide Phosphine Ligand; Asymmetric Synthesis Catalyst 1803239-58-8; Chiral P,N-Ligand; Sulfinyl Phosphine Ligand
EINECS	Contact for details

Quality Control

Our high-value chiral chemicals are produced and handled under strict quality management to ensure batch-to-batch consistency and optimal performance. Each lot undergoes comprehensive analytical characterization, including HPLC for chiral purity and assay, NMR for structural confirmation, and other relevant tests. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical specifications to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep the container under an inert atmosphere (e.g., nitrogen or argon) in a freezer at -20°C to maintain stability and prevent degradation. The material is moisture-sensitive and should be handled in a dry environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.