Description

[S(R)]-n-[(1S)-1-[(Diphenylphosphino)Methyl]-2-Methylpropyl]-2-Methyl-2-Propanesulfinamide is a high-value, chiral sulfinamide-phosphine hybrid ligand, a critical building block in asymmetric synthesis. Its core value lies in enabling highly enantioselective transformations, crucial for producing single-isomer active pharmaceutical ingredients (APIs) and advanced fine chemicals. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require precise stereochemical control.

Application

• As a chiral ligand in transition metal-catalyzed asymmetric reactions, such as hydrogenation, cross-coupling, and hydroformylation.
• Critical intermediate in the research and development of novel pharmaceutical candidates, particularly for central nervous system (CNS) and oncology targets.
• Used in the synthesis of asymmetric catalysts for the production of enantiomerically pure agrochemicals and flavors/fragrances.
• Facilitates methodology development in academic and industrial laboratories for creating new C-C and C-X bond-forming processes.
• Employed in the scale-up and process optimization of existing chiral drug manufacturing routes to improve yield and purity.

Basic Information

Product Name	[S(R)]-n-[(1S)-1-[(Diphenylphosphino)Methyl]-2-Methylpropyl]-2-Methyl-2-Propanesulfinamide
CAS No.	1803239-46-4
Molecular Formula	C21H30NOPS
Molecular Weight	375.51 g/mol
Synonyms	(S)-tert-Butanesulfinamide, (R)-2-((S)-1-((Diphenylphosphino)methyl)-2-methylpropyl)-2-methylpropane; (S)-N-[(1R)-1-[(Diphenylphosphino)methyl]-2-methylpropyl]-2-methylpropane-2-sulfinamide; Chiral Sulfinamide-Phosphine Ligand; tert-Butylsulfinyl P,N-Ligand; Asymmetric Sulfinamide Ligand; (S(R))-N-((S)-1-((Diphenylphosphino)methyl)-2-methylpropyl)-2-methylpropane-2-sulfinamide; P,N-Bidentate Ligand CAS 1803239-46-4
EINECS	Contact for details

Quality Control

Every batch of our chiral building blocks is produced under strict quality control protocols to ensure exceptional chemical and enantiomeric purity, which is paramount for reproducible asymmetric synthesis. We provide comprehensive Certificates of Analysis (COA) detailing purity, chiral HPLC analysis, and identity confirmation. Our quality systems are designed to meet the stringent requirements of GMP/GLP-compliant research and development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a dry, cool place. This compound is moisture-sensitive and easily oxidized; prolonged exposure to air or ambient conditions should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.