Description

[S(R)]-n-[(1S)-2-(Diphenylphosphino)-1-Phenylethyl]-2-Methyl-2-Propanesulfinamide is a high-purity, chiral sulfinamide-phosphine hybrid ligand, a critical component in asymmetric synthesis. Its value lies in its ability to induce high enantioselectivity in transition metal-catalyzed reactions, such as hydrogenations and cross-couplings, enabling the production of single-enantiomer intermediates. This compound is essential for research and development chemists in the pharmaceutical and fine chemical industries who require precise stereochemical control for creating active pharmaceutical ingredients (APIs) and advanced organic molecules.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for the synthesis of enantiomerically pure amino acids and amines.
• As a key catalyst component in enantioselective cross-coupling reactions to form carbon-carbon and carbon-heteroatom bonds.
• In the research and development of novel pharmaceutical intermediates and active pharmaceutical ingredients (APIs).
• For the synthesis of complex natural products and other fine chemicals requiring high stereochemical fidelity.
• As a tool compound in academic and industrial research to study and develop new asymmetric catalytic methodologies.
• In process chemistry for the scale-up and optimization of catalytic routes to chiral molecules.

Basic Information

Product Name	[S(R)]-n-[(1S)-2-(Diphenylphosphino)-1-Phenylethyl]-2-Methyl-2-Propanesulfinamide
CAS No.	1803239-44-2
Molecular Formula	C24H28NOPS
Molecular Weight	409.52 g/mol
Synonyms	(SR)-N-[(1S)-2-(Diphenylphosphino)-1-phenylethyl]-2-methylpropane-2-sulfinamide; (SR)-N-[(S)-2-(Diphenylphosphino)-1-phenylethyl]-P,P-diphenyl-tert-butylsulfinimidamide; (SR)-N-[(S)-2-(Diphenylphosphino)-1-phenylethyl]-2-methyl-2-propanesulfinamide; Chiral Sulfinamide-Phosphine Ligand; (SR,S)-Sulfinamide Phosphine Ligand; tert-Butanesulfinamide Derivative; Asymmetric Hydrogenation Ligand
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized and tested to meet stringent specifications for identity, purity, and chiral integrity, suitable for demanding applications in catalysis and pharmaceutical research. Certificates of Analysis (COA) are available upon request, detailing comprehensive analytical results from techniques including HPLC, NMR, and chiral analysis.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. This material is light-sensitive and easily oxidized; prolonged exposure to air or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.