Description

Pimozide-D4 is a deuterated analog of the antipsychotic drug pimozide, specifically labeled with four deuterium atoms. This stable isotope-labeled compound is a critical reference standard and internal standard in modern analytical chemistry, ensuring the accuracy and reliability of quantitative measurements. It is primarily utilized by pharmaceutical research laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and quality control.

Application

• Internal Standard for LC-MS/MS: Serves as a crucial, non-interfering internal standard in liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the precise quantification of pimozide in complex biological matrices like plasma, serum, and tissue homogenates.
• Drug Metabolism Studies (DMPK): Used in pharmacokinetic, bioavailability, and bioequivalence studies to track and quantify the parent drug and its metabolites, improving data accuracy by correcting for instrument variability and sample preparation losses.
• Bioanalytical Method Development and Validation: Essential for developing, optimizing, and validating robust, regulatory-compliant (FDA, EMA) analytical methods for pimozide assay in pharmaceutical and clinical research.
• Pharmaceutical Quality Control: Acts as a certified reference material (CRM) for calibrating instruments and verifying the purity and potency of pimozide in active pharmaceutical ingredient (API) and finished dosage form testing.
• Stable Isotope Labeling Studies: Employed in mechanistic studies to elucidate metabolic pathways and degradation products of pimozide using advanced mass spectrometric techniques.

Basic Information

Product Name	Pimozide-D4
CAS No.	1803193-57-8
Molecular Formula	C28H25D4F2N3O
Molecular Weight	465.56 g/mol
Synonyms	1-[1-[4,4-Bis(4-fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one-d4; Pimozide (tetradeuterated); Pimozide-d4; Deuterated Pimozide; Pimozide Internal Standard; Pimozide Stable Isotope; Pimozide D4; CAS 1803193-57-8
EINECS	Contact for details

Quality Control

Our Pimozide-D4 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR (1H, 13C) and high-resolution mass spectrometry (HRMS) for structural confirmation and isotopic enrichment verification. Purity is determined via HPLC with UV and/or MS detection. A comprehensive Certificate of Analysis (COA) detailing batch-specific data on chemical purity, isotopic purity (atom % D), and residual solvents is provided with every shipment to ensure traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or CoA. This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0% (chemical purity)
Isotopic Purity	≥98.0 atom % D (by MS)
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.