Description

Methyltetrazine-Dbco CAS NO 1802238-48-7 is a high-purity, bifunctional linker reagent designed for advanced bioconjugation and click chemistry applications. This compound is critical for researchers and manufacturers requiring precise, stable, and efficient cross-linking of biomolecules, such as antibodies, peptides, and oligonucleotides. It is primarily utilized in the pharmaceutical, diagnostic, and life science research sectors for developing targeted therapeutics, imaging agents, and sophisticated assay platforms.

Application

• Antibody-Drug Conjugate (ADC) Development: Enables site-specific conjugation of cytotoxic payloads to monoclonal antibodies via bioorthogonal click chemistry.
• Fluorescent Probe & Imaging Agent Synthesis: Used to attach fluorophores or other imaging moieties to targeting vectors for in vitro and in vivo diagnostics.
• Surface Functionalization & Biomaterial Engineering: Facilitates the modification of nanoparticles, polymers, and solid supports with bioactive ligands.
• Protein & Peptide Labeling: Allows for the stable, covalent tagging of proteins and peptides for pull-down assays, mass spectrometry, and structural studies.
• Nucleic Acid Modification: Employed in the conjugation of oligonucleotides with various functional groups for therapeutic and diagnostic applications.
• Polymer & Dendrimer Cross-linking: Serves as a key building block in the synthesis of advanced polymeric materials with tailored biological properties.

Basic Information

Product Name	Methyltetrazine-Dbco
CAS No.	1802238-48-7
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.42 g/mol
Synonyms	DBCO-Methyltetrazine; Methyltetrazine-DBCO; 3-(4-(1,2,4,5-Tetrazin-3-yl)phenyl)propanoic acid DBCO ester; Dibenzocyclooctyne-PEG4-Methyltetrazine; DBCO-PEG4-Methyltetrazine; Methyltetrazine-PEG4-DBCO; (1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl N-(2,5-dioxopyrrolidin-1-yl) (14-(6-methyl-1,2,4,5-tetrazin-3-yl)-3,6,9,12-tetraoxatetradec-1-yl) carbamate
EINECS	Contact for details

Quality Control

Every batch of Methyltetrazine-Dbco undergoes rigorous analytical testing to ensure identity, purity, and performance consistency suitable for sensitive research and development applications. Our quality commitment includes comprehensive analysis via HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with stringent in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, freezer. This product is hygroscopic (moisture-sensitive) and easily oxidized. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Red to purple solid or film
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.