Description

Cabozantinib-D6 is a deuterated isotopologue of the multi-targeted receptor tyrosine kinase inhibitor Cabozantinib, specifically labeled with six deuterium atoms. This stable isotope-labeled compound is an essential internal standard for the precise and accurate quantification of Cabozantinib in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is a critical tool for pharmaceutical R&D and bioanalytical laboratories focused on drug metabolism and pharmacokinetics (DMPK) studies, therapeutic drug monitoring, and ensuring regulatory compliance in clinical trials.

Application

• Bioanalytical Reference Standard: Serves as a primary internal standard for the quantitative analysis of Cabozantinib in plasma, serum, and tissue homogenates via mass spectrometry.
• Drug Metabolism & Pharmacokinetics (DMPK): Enables accurate tracking of absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical studies.
• Clinical Research & Therapeutic Drug Monitoring (TDM): Facilitates precise measurement of drug concentrations in patient samples to optimize dosing regimens and ensure therapeutic efficacy.
• Pharmaceutical Quality Control: Used in method development and validation to ensure the specificity and accuracy of assays for active pharmaceutical ingredient (API) quantification.
• Metabolite Identification Studies: Aids in distinguishing drug-derived metabolites from endogenous compounds in complex biological samples.

Basic Information

Product Name	Cabozantinib-D6
CAS No.	1802168-46-2
Molecular Formula	C28H18D6FN4O4
Molecular Weight	504.54 g/mol
Synonyms	Cabozantinib-d6; (S)-N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide-d6; BMS-907351-d6; XL184-d6; Cometriq-d6; Cabometyx-d6; Cabozanib-d6; Cabozantinib (hexadeuterated)
EINECS	Contact for details

Quality Control

Every batch of Cabozantinib-D6 is manufactured under strict quality management systems and undergoes comprehensive analytical characterization to ensure identity, purity, and isotopic enrichment. Our products are supplied with a detailed Certificate of Analysis (COA) that includes data from NMR (1H, 13C), mass spectrometry, HPLC for chemical and isotopic purity, and residual solvent analysis. We adhere to the highest standards suitable for research and bioanalytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This compound is hygroscopic (moisture-sensitive). For long-term storage, consider storage under an inert atmosphere. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0% (Chemical Purity)
Isotopic Purity (MS)	≥98.0 atom % D
Isotopic Enrichment	≥95.0% (D6)
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.