Description

5-Fam-Amyloid β-Protein (1-42) CAS NO 1802087-78-0 is a fluorescently labeled derivative of the amyloid-beta peptide, a key biomarker in Alzheimer's disease research. This compound is specifically designed for advanced biochemical and biophysical studies, offering enhanced detection capabilities without significantly altering the peptide's native aggregation properties. It is an essential tool for researchers and pharmaceutical developers in neuroscience, diagnostics, and drug discovery, enabling precise tracking of peptide behavior in complex biological systems.

Application

• Biomarker Research: Fluorescent tagging for the study of amyloid-beta aggregation kinetics, oligomer formation, and fibrillogenesis in Alzheimer's disease models.
• Drug Discovery Screening: High-throughput assay development to identify and evaluate potential therapeutic compounds that inhibit or modulate amyloid-beta aggregation.
• Cellular & Molecular Imaging: Visualization and tracking of amyloid-beta peptide uptake, localization, and cytotoxicity in live-cell and tissue imaging applications.
• Diagnostic Assay Development: Serving as a critical component in the development of sensitive in vitro diagnostic (IVD) kits and biosensors for early disease detection.
• Biophysical Characterization: Utilization in techniques such as fluorescence polarization (FP), Förster resonance energy transfer (FRET), and surface plasmon resonance (SPR) to study protein-protein interactions.
• Neuroscience & Toxicology Studies: Investigation of the neurotoxic mechanisms of amyloid-beta peptides and their role in neurodegenerative pathways.

Basic Information

Product Name	5-Fam-Amyloid β-Protein (1-42)
CAS No.	1802087-78-0
Molecular Formula	C226H340N58O68S
Molecular Weight	~ 4760.5 g/mol
Synonyms	5-FAM-Aβ(1-42); 5-Carboxyfluorescein labeled Amyloid β-Protein (1-42); FAM-Aβ42; Fluorescein-Amyloid Beta (1-42); Aβ(1-42)-5-FAM; 5-FAM-Aβ42 Peptide; Fluorescent Amyloid-β Peptide; 5-FAM-H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH
EINECS	Contact for details

Quality Control

Our 5-Fam-Amyloid β-Protein (1-42) is produced under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for critical research applications. Each lot undergoes comprehensive analytical characterization, including reverse-phase HPLC for purity assessment and mass spectrometry (MS) for identity confirmation. Certificates of Analysis (COA) detailing purity, peptide content, and fluorescence properties are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Analysis	Within ± 10% of theoretical
Fluorescence Properties	Ex/Em ~492/518 nm (verify in buffer)
Solubility	Soluble in DMSO, DMF, or basic aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.