Description

Fitc-β-Ala-Amyloid β-Protein (1-42) CAS NO 1802087-77-9 is a fluorescently labeled derivative of the amyloid beta peptide, a key protein fragment in Alzheimer's disease research. This compound is specifically designed for advanced biochemical and cellular studies, offering a powerful tool for tracking and visualization. It is essential for researchers and developers in pharmaceutical R&D, diagnostic assay development, and neuroscience who require high-purity, well-characterized probes for studying protein aggregation, cellular uptake, and biomarker detection.

Application

• Alzheimer's Disease Research: Used as a fluorescent tracer in studies of amyloid-beta aggregation kinetics, fibril formation, and neurotoxicity mechanisms.
• High-Content Screening (HCS): Serves as a critical reagent in cell-based assays for screening potential therapeutic compounds that inhibit amyloid plaque formation.
• Biomarker Detection & Diagnostic Development: Employed in the development and validation of immunoassays and biosensors for detecting amyloid-beta peptides in biological samples.
• Cellular Imaging & Microscopy: Facilitates real-time visualization and tracking of amyloid-beta peptide internalization, localization, and interaction with neuronal cells using fluorescence microscopy (e.g., confocal, TIRF).
• Protein-Protein Interaction Studies: Acts as a fluorescent probe in fluorescence polarization (FP) or fluorescence resonance energy transfer (FRET) assays to study interactions with antibodies, receptors, or other proteins.
• Quality Control for Antibody Production: Used as a reference standard or coating antigen to evaluate the specificity and affinity of anti-amyloid beta antibodies.

Basic Information

Product Name	Fitc-β-Ala-Amyloid β-Protein (1-42)
CAS No.	1802087-77-9
Molecular Formula	C226H340N56O69S
Molecular Weight	~4514.5 g/mol
Synonyms	FITC-β-Ala-Aβ(1-42); Fluorescein Isothiocyanate labeled Amyloid Beta Peptide (1-42); FITC-β-Alanine-Amyloid β-Protein (1-42); Aβ(1-42)-FITC conjugate; Fluorescent Amyloid-β 1-42; FITC-Aβ42; Aβ42-FITC; FITC-labeled DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
EINECS	Contact for details

Quality Control

Our Fitc-β-Ala-Amyloid β-Protein (1-42) is produced under stringent conditions to ensure batch-to-batch consistency and high performance in sensitive research applications. Quality is verified through a comprehensive suite of analytical techniques, including reverse-phase HPLC for purity assessment, mass spectrometry (MS) for identity confirmation, and absorbance spectroscopy for fluorophore quantification. Certificates of Analysis (COA) detailing purity, concentration, and performance data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot into single-use quantities to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	Yellow to orange lyophilized powder
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Fluorophore-to-Peptide Ratio (F/P)	~1.0 (by absorbance)
Solubility	Soluble in DMSO, DMF, or dilute basic aqueous buffers
Endotoxin Level	< 1.0 EU/mg (for cell culture grades)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.