Description

Fitc-β-Ala-Amyloid β-Protein (1-40) CAS NO 1802087-76-8 is a fluorescently labeled peptide derivative, specifically the 1-40 fragment of the amyloid beta protein conjugated with fluorescein isothiocyanate (FITC) via a β-alanine linker. This compound is a critical research tool for studying the aggregation, localization, and cellular interactions of amyloid beta peptides, which are central to Alzheimer's disease pathology. It is primarily utilized by researchers and scientists in the fields of neuroscience, biochemistry, and pharmaceutical development for fluorescence microscopy, flow cytometry, and in vitro binding assays.

Application

• Biomedical Research: Fundamental studies on the aggregation kinetics, toxicity, and structural properties of amyloid beta peptides in Alzheimer's disease models.
• Cellular Imaging: Visualization and tracking of amyloid beta peptide uptake, internalization, and intracellular localization in neuronal and glial cell cultures using fluorescence microscopy.
• High-Throughput Screening (HTS): Development and validation of assays to screen for potential therapeutic compounds that inhibit amyloid beta aggregation or promote its clearance.
• Binding Studies: Investigation of interactions between amyloid beta peptides and other proteins, receptors, or potential drug candidates using fluorescence-based techniques like FRET or polarization.
• In Vitro Diagnostics Development: Serving as a key component in the research phase for developing diagnostic kits targeting amyloid beta species.
• Neuroscience & Pharmacology: Elucidating the mechanisms of amyloid beta in neuroinflammation, synaptic dysfunction, and blood-brain barrier penetration.

Basic Information

Item	Information
Product Name	Fitc-β-Ala-Amyloid β-Protein (1-40)
CAS No.	1802087-76-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	FITC-β-Ala-Aβ(1-40); Fluorescein Isothiocyanate labeled Amyloid Beta Protein (1-40); FITC-Amyloid β-Protein (1-40); FITC-Aβ40; Aβ40-FITC; Aβ(1-40)-FITC conjugate; Fluorescent Amyloid Beta 1-40; FITC-conjugated Amyloid β (1-40) Peptide
EINECS	Contact for details

Quality Control

Our Fitc-β-Ala-Amyloid β-Protein (1-40) is produced under stringent conditions to ensure high purity and batch-to-batch consistency, critical for reproducible research outcomes. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and mass spectrometry for identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the purity, peptide content, and fluorescence properties.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive) and strictly light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Yellow to orange solid (lyophilized powder)
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70%
Extinction Coefficient	~68,000 cm⁻¹M⁻¹ at 494 nm (FITC)
Solubility	Soluble in DMSO, DMF, or aqueous buffers (e.g., PBS)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.