Description

β-Amyloid (1-40) (S26C) Dimer is a specifically engineered, covalently linked dimeric form of the amyloid-beta peptide, featuring a cysteine substitution at position 26. This modified peptide is a critical research tool for studying the molecular mechanisms of Alzheimer's disease, particularly the early oligomerization events linked to neurotoxicity. It is essential for academic, pharmaceutical, and biotechnology researchers focused on neurodegenerative disease modeling, drug discovery, and diagnostic assay development.

Application

• Alzheimer's Disease Research: Used as a defined oligomeric standard to study aggregation kinetics, toxicity pathways, and structure-activity relationships.
• Drug Discovery Screening: Serves as a key target or reagent in high-throughput assays to identify and validate potential therapeutic compounds that inhibit amyloid aggregation.
• Antibody & Diagnostic Development: Critical for the characterization and validation of antibodies, biosensors, and diagnostic kits designed to detect specific amyloid-beta oligomers.
• Biophysical Studies: Employed in techniques such as NMR, X-ray crystallography, and electron microscopy to elucidate the structural properties of amyloid dimers.
• Cellular & Animal Model Studies: Used to induce and model amyloid-related pathology in cell cultures and transgenic animal models to assess therapeutic interventions.

Basic Information

Product Name	β-Amyloid (1-40) (S26C) Dimer
CAS No.	1802087-75-7
Molecular Formula	C194H295N55O58S2
Molecular Weight	4333.9 g/mol (monoisotopic)
Synonyms	β-Amyloid (1-40) (S26C) Dimer; Aβ40 S26C Dimer; Amyloid Beta Peptide (1-40) Cys26 Dimer; DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA (S26C) Dimer; Aβ (1-40) C26S Dimer; Covalent Aβ40 Dimer; Research-grade Amyloid Dimer
EINECS	Contact for details

Quality Control

Our β-Amyloid (1-40) (S26C) Dimer is produced and analyzed under stringent conditions to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and oligomeric state verification. We adhere to ISO 9001 quality management principles, and our processes are designed to support research requiring the highest standards of reproducibility.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot into single-use vials to minimize freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Dimer Content (Non-reducing SDS-PAGE/LC-MS)	≥ 90%
Molecular Weight (MS)	4333.9 ± 2.0 Da
Water Content (KF)	≤ 5.0%
Solubility	Soluble in 1% NH4OH or DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.