Description

(Met(O)3)-Amyloid β-Protein (1-42) CAS NO 1802086-69-6 is a chemically modified peptide variant of the amyloid-beta protein, specifically oxidized at three methionine residues, which is critical for studying oxidative stress mechanisms in neurodegenerative disease research. This high-purity reference standard is essential for advancing the understanding of Alzheimer's disease pathology and for the development of targeted diagnostic and therapeutic strategies. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on neuroscience and protein biochemistry.

Application

• Biomedical Research: A key reference standard in Alzheimer's disease research for investigating the role of methionine oxidation in amyloid-beta aggregation, toxicity, and plaque formation.
• Drug Discovery & Development: Used in high-throughput screening assays and in vitro models to evaluate the efficacy of novel therapeutic compounds targeting oxidized amyloid-beta species.
• Diagnostic Assay Development: Serves as a critical antigen and calibrator in the development of immunoassays (ELISA, Western Blot) designed to detect specific oxidized forms of amyloid-beta in biological samples.
• Mechanistic Studies: Enables detailed biochemical and biophysical studies to understand the structural and functional consequences of protein oxidation in neurodegenerative processes.
• Quality Control & Standardization: Provides a defined standard for the quality control of related reagents, antibodies, and assay kits within the life science supply chain.

Basic Information

Product Name	(Met(O)3)-Amyloid β-Protein (1-42)
CAS No.	1802086-69-6
Molecular Formula	C203H311N55O60S
Molecular Weight	4514.0 g/mol
Synonyms	Abeta (1-42) (Met(O)3); Oxidized Amyloid Beta Peptide (1-42); Aβ1-42 (Met(O)3); DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA (with oxidized Met35); Amyloid β-Peptide (1-42) (human) (Met(O)3); (Met(O)3)-Aβ(1-42); (Met(O)3)-Amyloid β (1-42); Methionine-Sulfoxide Amyloid-β
EINECS	Contact for details

Quality Control

Our (Met(O)3)-Amyloid β-Protein (1-42) is manufactured under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and oxidation verification. We adhere to quality management principles aligned with ISO standards to support our global clientele in pharmaceutical and academic research.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot into single-use quantities to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by amino acid analysis)
Oxidation Verification (MS)	Confirmation of Met(O)3 modification
Solubility	Soluble in dilute ammonia solution or DMSO
Endotoxin Level	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.