Description

(Met(O)3)-Amyloid β-Protein (1-42) CAS NO 1802086-68-5 is a chemically modified peptide variant of the amyloid-beta protein, a key molecule in Alzheimer's disease research. This specific oxidized form, with methionine sulfoxide at three positions, is critical for studying oxidative stress mechanisms and protein aggregation pathology in neurodegenerative conditions. It is an essential research-grade biochemical for pharmaceutical R&D, academic institutions, and diagnostic developers focused on neurobiology and therapeutic discovery.

Application

• Biomedical Research: Fundamental studies on the role of oxidative modification in amyloid-beta aggregation kinetics, toxicity, and oligomer formation.
• Drug Discovery & Screening: A key target molecule for high-throughput screening (HTS) assays to identify potential inhibitors of oxidized amyloid-beta aggregation or toxicity.
• Antibody & Diagnostic Development: Used as an antigen for generating and characterizing antibodies specific to oxidized forms of amyloid-beta, crucial for advanced diagnostic immunoassays.
• Mechanistic Studies: Investigating the impact of methionine sulfoxidation on peptide structure, membrane interaction, and cellular signaling pathways relevant to Alzheimer's disease.
• Biomarker Research: Serving as a standard reference material in mass spectrometry and chromatography-based methods to detect and quantify oxidized Aβ species in biological samples.
• Model System Development: Utilized in creating more physiologically relevant in vitro and in vivo models of Alzheimer's pathology that incorporate oxidative damage components.

Basic Information

Item	Details
Product Name	(Met(O)3)-Amyloid β-Protein (1-42)
CAS No.	1802086-68-5
Molecular Formula	C203H311N55O60S3
Molecular Weight	4514.1 g/mol (monoisotopic)
Synonyms	Oxidized Amyloid-beta (1-42); Aβ(1-42) with Methionine Sulfoxide; Met(O)-Aβ42; Oxidized Aβ42; Amyloid β-Peptide (1-42) (oxidized); Aβ1-42 (Met(O)3); Alzheimer's Disease Peptide (oxidized form); DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA (with Met35 oxidized)
EINECS	Contact for details

Quality Control

Our (Met(O)3)-Amyloid β-Protein (1-42) is produced and analyzed under stringent conditions to ensure high purity and batch-to-batch consistency, essential for reproducible research. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and content. We adhere to rigorous quality standards appropriate for research biochemicals. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot into single-use quantities to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Molecular Weight (MS)	4514.1 ± 2.0 Da
Oxidation State (MS)	Confirmation of three methionine sulfoxide residues
Solubility	Soluble in dilute ammonia solution or DMSO
Endotoxin Level	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.