Description

(Nle3)-Amyloid β-Protein (1-42) Ammonium Salt is a high-purity, synthetic peptide analog of the amyloid beta protein, specifically engineered with a norleucine substitution at position 3. This modification enhances its stability for research applications, making it a critical tool for studying the mechanisms of amyloid aggregation and neurotoxicity associated with Alzheimer's disease. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on neurodegenerative disease modeling and therapeutic discovery.

Application

• Alzheimer's Disease Research: Used as a key reagent for in vitro and in vivo studies of amyloid-beta aggregation, fibril formation, and associated cytotoxicity.
• Drug Discovery Screening: Serves as a target substrate in high-throughput assays to identify and validate potential inhibitors of amyloid-beta aggregation.
• Biomarker Development: Employed in the development and calibration of diagnostic assays and imaging agents designed to detect amyloid plaques.
• Antibody & Therapeutic Protein Characterization: Used to test the binding affinity and specificity of candidate therapeutic antibodies or proteins targeting amyloid-beta.
• Neuroscience & Cell Biology Studies: Applied in cell culture models to investigate the cellular pathways and toxicity mechanisms induced by amyloid-beta peptides.
• Reference Standard: Functions as a well-defined analytical standard for mass spectrometry, HPLC, and other characterization techniques in quality control laboratories.

Basic Information

Product Name	(Nle3)-Amyloid β-Protein (1-42) Ammonium Salt
CAS No.	1802086-51-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Abeta (1-42) (Nle3); Amyloid Beta Peptide (1-42) (Nle3) ammonium salt; Aβ1-42 (Nle3); DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA (Nle3); Norleucine3-Amyloid β-Protein (1-42); Nle3-Aβ42; Synthetic Amyloid-β (1-42) analog
EINECS	Contact for details

Quality Control

Our (Nle3)-Amyloid β-Protein (1-42) Ammonium Salt is manufactured under controlled conditions to ensure batch-to-batch consistency and high biological activity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and peptide content. We adhere to stringent quality protocols suitable for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.