Description

(Gly22)-Amyloid β-Protein (1-42) is a specifically modified peptide variant of the amyloid-beta protein, a key molecule in neurological research. This compound matters for its role in modeling specific biochemical interactions and aggregation pathways associated with neurodegenerative studies. Researchers in pharmaceutical R&D, academic biochemistry, and diagnostic development need it for advanced studies on protein misfolding, inhibitor screening, and the development of targeted therapeutic and diagnostic agents.

Application

• Biochemical Research: Fundamental studies on amyloid-beta protein structure, folding kinetics, and aggregation mechanisms.
• Therapeutic Development: Screening and evaluation of potential drug candidates designed to inhibit or modulate specific amyloid-beta aggregation pathways.
• Diagnostic Assay Development: Used as a critical reference standard or antigen in the development of immunoassays and biosensors for detecting amyloid-related biomarkers.
• Neuroscience Studies: In vitro modeling of protein-protein interactions relevant to Alzheimer's disease and other neurodegenerative conditions.
• Peptide Chemistry: Serving as a substrate or intermediate in peptide synthesis and modification research.
• Quality Control Reference: Acting as a high-purity standard for calibrating analytical instruments and validating testing protocols in QC laboratories.

Basic Information

Product Name	(Gly22)-Amyloid β-Protein (1-42)
CAS No.	1802086-23-2
Molecular Formula	C203H311N55O60S
Molecular Weight	4514.0 g/mol (approximately)
Synonyms	Abeta (1-42) Gly22; Aβ42 (Gly22); Amyloid β-Protein (1-42) (Gly22 variant); DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA (single letter code with G22 substitution); Aβ1-42 (G22); (Gly22)-Aβ42; Modified Amyloid-β (1-42) Peptide
EINECS	Contact for details

Quality Control

Our (Gly22)-Amyloid β-Protein (1-42) is produced under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and mass spectrometry for identity confirmation. Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Mass Spec)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.