Description

Cys-Gly-Lys-Arg-Amyloid - β Protein (1-42) CAS NO 1802086-21-0 is a synthetic peptide fragment corresponding to a specific sequence of the amyloid-beta protein, a key molecule in Alzheimer's disease research. This high-purity compound is critical for advancing scientific understanding of protein aggregation mechanisms and neurotoxicity. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic developers focused on neurodegenerative diseases and therapeutic target validation.

Application

• Biomedical Research: Fundamental studies on the structure, aggregation kinetics, and toxicity of amyloid-beta peptides in Alzheimer's disease pathology.
• Drug Discovery & Screening: Serving as a key target or reagent in high-throughput screening assays to identify potential inhibitors of amyloid-beta aggregation or oligomerization.
• Antibody & Diagnostic Development: Used as an antigen for the production and characterization of specific antibodies, and in the development of immunoassays and diagnostic kits.
• Biophysical Studies: Employed in techniques such as NMR, X-ray crystallography, and surface plasmon resonance (SPR) to investigate molecular interactions and conformational changes.
• Cell Culture & In Vitro Models: Application in neuronal cell culture studies to model amyloid-induced cytotoxicity and evaluate neuroprotective compounds.
• Reference Standard: Acting as a certified reference material (CRM) for quality control and method validation in analytical laboratories.

Basic Information

Product Name	Cys-Gly-Lys-Arg-Amyloid - β Protein (1-42)
CAS No.	1802086-21-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Amyloid β-Protein (1-42), Cys-Gly-Lys-Arg-Aβ(1-42); Aβ(1-42) peptide; β-Amyloid Peptide (1-42); Amyloid β-Peptide (1-42); Alzheimer's Disease Amyloid Peptide; Aβ42; Synthetic Aβ42
EINECS	Contact for details

Quality Control

Our Cys-Gly-Lys-Arg-Amyloid - β Protein (1-42) is manufactured under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to GMP principles for production and quality management, ensuring traceability and reliability for our global clientele in pharmaceutical and academic research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store desiccated at -80°C. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.