Description

(Arg17)-Amyloid β-Protein (1-42) CAS NO 1802085-97-7 is a specific, arginine-substituted variant of the amyloid-beta peptide, a key molecule in neurological research. This high-purity synthetic peptide is critical for studying the molecular mechanisms underlying protein aggregation and its role in neurodegenerative conditions. It is an essential research-grade biochemical for academic institutions, pharmaceutical R&D departments, and biotechnology companies focused on neuroscience, drug discovery, and diagnostic development.

Application

• Neuroscience Research: Fundamental studies on amyloid-beta aggregation kinetics, fibril formation, and oligomer toxicity.
• Drug Discovery Screening: Used as a target substrate in high-throughput assays to identify and validate potential therapeutic inhibitors of amyloid aggregation.
• Biomarker & Diagnostic Development: Serves as a critical reference standard in the development and calibration of immunoassays (ELISA, Western Blot) and biosensors for detecting amyloid-beta isoforms.
• Structural Biology Studies: Employed in techniques like NMR spectroscopy and X-ray crystallography to elucidate the three-dimensional structure and interaction sites of modified amyloid peptides.
• Cell Culture & In Vitro Models: Used to treat neuronal cell cultures to model cellular stress and toxicity pathways associated with protein misfolding diseases.
• Antibody Production & Characterization: Acts as a specialized immunogen for generating and testing the specificity of monoclonal or polyclonal antibodies targeting specific amyloid-beta epitopes.

Basic Information

Product Name	(Arg17)-Amyloid β-Protein (1-42)
CAS No.	1802085-97-7
Molecular Formula	C203H311N57O60S
Molecular Weight	4514.0 g/mol
Synonyms	Aβ(1-42) R17; Aβ42 (R17); Amyloid β-Protein (1-42) Arg17 variant; DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA (Arg17); H-DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA-OH (Arg17); Aβ1-42 (R17); Arg17-Aβ42; 17R-Aβ(1-42)
EINECS	Contact for details

Quality Control

Our research-grade peptides are manufactured under strict quality systems. Each batch of (Arg17)-Amyloid β-Protein (1-42) undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing HPLC purity, mass spectrometry (MS) confirmation, and endotoxin levels are provided with every shipment to support your critical research data integrity.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot into single-use vials to minimize freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Mass Spec)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Solubility	Soluble in 1% NH4OH or DMSO
Endotoxin Level	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.