Description

Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770(667-675)-Lys(Dnp) Ammonium Acetate Salt is a chemically modified peptide fragment derived from the amyloid precursor protein (APP), a key molecule in Alzheimer's disease research. This high-purity reference standard is critical for calibrating analytical instruments and validating experimental assays in proteomics and neuroscience. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and diagnostic kit manufacturers focused on neurodegenerative disease mechanisms and biomarker discovery.

Application

• Biochemical Research: Used as a precise reference standard in mass spectrometry (MS) and high-performance liquid chromatography (HPLC) for the quantification and characterization of APP-derived peptides.
• Neuroscience Studies: Serves as a critical tool for investigating the proteolytic processing pathways of APP and the formation of amyloid-beta peptides in Alzheimer's disease models.
• Assay Development & Validation: Essential for developing and calibrating enzyme-linked immunosorbent assays (ELISAs), Western blotting, and other immunoassays targeting specific APP epitopes.
• Pharmaceutical Screening: Acts as a substrate or control compound in high-throughput screening (HTS) campaigns to identify potential therapeutic agents that modulate APP processing.
• Diagnostic Reference Material: Provides a traceable standard for quality control in the manufacturing of in-vitro diagnostic (IVD) devices for neurological conditions.
• Proteomic Analysis: Employed in peptide mapping and protein sequencing studies to understand post-translational modifications and protein interactions.

Basic Information

Product Name	Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770(667-675)-Lys(Dnp) Ammonium Acetate Salt
CAS No.	1802078-31-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	APP(667-675) (Mca-Asn-Leu) Lys(Dnp) ammonium acetate; Amyloid beta A4 protein precursor (667-675), 7-Methoxycoumarin-4-acetyl-Asn-Leu-Lys(2,4-Dinitrophenyl)-OH ammonium salt; Mca-APP(667-675)-Lys(Dnp) ammonium acetate; Fluorogenic substrate for APP secretases; APP770 fragment (667-675) modified peptide; Mca-NL-K(Dnp) ammonium acetate (APP-derived); Alzheimer's disease research peptide standard.
EINECS	Contact for details

Quality Control

This peptide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by comprehensive analytical data, including HPLC purity and mass spectrometry (MS) confirmation. Certificates of Analysis (COA) detailing identity, purity, and peptide content are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This compound is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.