Description

Exendin-4 (1-8) is a synthetic peptide fragment derived from the N-terminal sequence of the glucagon-like peptide-1 (GLP-1) receptor agonist Exendin-4. This compound is a critical intermediate and research tool for the development of novel therapeutics targeting metabolic disorders such as type 2 diabetes and obesity. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions engaged in peptide synthesis, drug discovery, and metabolic pathway studies.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate in the synthesis of novel GLP-1 receptor agonists and analogs for metabolic disease treatment.
• Biochemical Research: Used as a reference standard and tool compound for studying GLP-1 receptor binding, activation, and downstream signaling pathways.
• Peptide Chemistry: Employed as a building block in solid-phase and solution-phase peptide synthesis for creating modified peptide sequences.
• Drug Discovery Screening: Acts as a core structure in high-throughput screening assays to identify and optimize new drug candidates targeting incretin receptors.
• Academic Studies: Utilized in university and institutional labs for fundamental research on insulin secretion, appetite regulation, and pancreatic function.
• Preclinical Development: Supports the development and characterization of long-acting or conjugated peptide therapeutics for improved pharmacokinetic profiles.

Basic Information

Product Name	Exendin-4 (1-8)
CAS No.	1802078-29-0
Molecular Formula	C36H56N10O12S
Molecular Weight	852.96 g/mol
Synonyms	Exendin-4 Fragment (1-8); HGEGTFTSD; H-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-OH; Exendin (1-8); Exenatide (1-8) fragment; GLP-1 receptor agonist fragment; HGEGTFTS-NH2 (Amidated form); HGEGTFTSD-OH (Acid form)
EINECS	Contact for details

Quality Control

Our Exendin-4 (1-8) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide full traceability and documentation. Certificates of Analysis (COA) detailing purity, peptide content, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Composition	Within ±10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.