Description

Amyloid Bri Protein Precursor277 (89-106) CAS NO 1802078-21-2 is a defined synthetic peptide fragment corresponding to residues 89-106 of the Amyloid Bri Protein Precursor277. This high-purity peptide is a critical research tool for investigating the molecular mechanisms of Familial British Dementia (FBD) and related amyloidogenic disorders. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic developers focused on neurodegenerative disease pathology and therapeutic target validation.

Application

• Biomedical Research: Fundamental studies on the aggregation kinetics, structural properties, and neurotoxicity of amyloid peptides associated with Familial British Dementia.
• Therapeutic Development: Serving as a key antigen or target molecule in the screening and validation of potential inhibitors, antibodies, or small molecules designed to prevent amyloid fibril formation.
• Diagnostic Assay Development: Use as a calibrated standard or coating antigen in the development of immunoassays (ELISA, Western Blot) for detecting amyloid-related biomarkers.
• Structural Biology: Enabling NMR, X-ray crystallography, and other biophysical studies to elucidate the three-dimensional conformation of the peptide and its interaction with other biological molecules.
• Cell Culture & In Vitro Models: Application in cell-based assays to study peptide-induced cytotoxicity, cellular uptake, and the downstream effects on neuronal pathways.
• Antibody Production: Acting as an immunogen for generating specific polyclonal or monoclonal antibodies against the Bri protein fragment for research and diagnostic purposes.

Basic Information

Product Name	Amyloid Bri Protein Precursor277 (89-106)
CAS No.	1802078-21-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	ABri (89-106) Peptide; Amyloid Bri Protein (89-106); Bri Peptide Fragment 89-106; ABri Peptide; Familial British Dementia-Related Peptide; ITM2B (89-106); ITM2B Peptide Fragment; Synthetic ABri Fragment
EINECS	Contact for details

Quality Control

Our Amyloid Bri Protein Precursor277 (89-106) is manufactured under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including mass spectrometry (MS) for identity confirmation and high-performance liquid chromatography (HPLC) for purity assessment. A comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and analytical data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70%
Amino Acid Analysis	Conforms to theoretical composition
Solubility	Soluble in water or appropriate aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.