Description

(4E)-Tco-Peg3-Amine is a heterobifunctional polyethylene glycol (PEG) linker featuring a trans-cyclooctene (TCO) group and a primary amine. This compound is specifically engineered for bioorthogonal click chemistry applications, enabling rapid and selective conjugation under mild, physiological conditions. It is an essential reagent for researchers and manufacturers in bioconjugation, pharmaceutical development, and advanced material science, where precise and stable linkage of biomolecules is required.

Application

• Bioorthogonal Labeling and Imaging: Conjugation of fluorescent dyes, probes, or contrast agents to antibodies, proteins, or nanoparticles for in vitro and in vivo imaging studies.
• Antibody-Drug Conjugate (ADC) Development: Site-specific coupling of cytotoxic payloads to monoclonal antibodies via the amine-reactive end, utilizing the rapid TCO-tetrazine click reaction for efficient assembly.
• PEGylation and Surface Modification: Introduction of a hydrophilic PEG spacer and a reactive TCO handle onto peptides, proteins, or solid surfaces to improve solubility, stability, and enable subsequent functionalization.
• Prodrug Synthesis: Construction of targeted prodrug systems where the active drug is tethered via a cleavable linker for controlled release.
• Hydrogel and Biomaterial Fabrication: Cross-linking agent for creating functionalized hydrogels with tunable properties for drug delivery and tissue engineering scaffolds.
• Diagnostic Assay Development: Key component in the development of sensitive immunoassays and biosensors by facilitating stable immobilization of capture molecules.

Basic Information

Product Name	(4E)-Tco-Peg3-Amine
CAS No.	1800507-93-0
Molecular Formula	C₂₀H₃₇N₂O₄⁺ (as a salt, typically TFA or HCl)
Molecular Weight	Contact for details
Synonyms	trans-Cyclooctene-PEG3-Amine; TCO-PEG3-NH2; (E)-Cyclooct-4-enyl-PEG3-Amine; 1-Amino-3,6,9-trioxa-12-azatetradec-13-en-14-oic acid, 14-[(1E,5E)-cycloocta-1,5-dien-1-yl]-13-oxo-; TCO-PEG3-amine hydrochloride; Amine-PEG3-TCO; 4E-TCO-PEG3-NH2
EINECS	Contact for details

Quality Control

Our (4E)-Tco-Peg3-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure identity, strength, and composition. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee reproducibility and reliability for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid or oil
Identification (NMR)	Complies with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.