Description

3-Chloro-2,4-Difluorophenylboronic Acid Pinacol Ester is a high-purity, protected boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex molecules. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for the development of new active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting complex heterocycles.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, where the difluoro and chloro substituents impart specific biological activity.
• Material Science Research: Employed in the creation of organic electronic materials, such as OLEDs and semiconductors, where precise molecular architecture is required.
• Chemical Biology Probes: Acts as a versatile handle for bioconjugation and the synthesis of molecular probes used in diagnostic and biochemical research.
• Scale-up Process Development: Suitable for process optimization and pilot-scale synthesis due to the stability provided by the pinacol ester protecting group.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and proprietary intermediates.

Basic Information

Item	Detail
Product Name	3-Chloro-2,4-Difluorophenylboronic Acid Pinacol Ester
CAS No.	1799614-91-7
Molecular Formula	C12H14BClF2O2
Molecular Weight	274.50 g/mol
Synonyms	3-Chloro-2,4-difluorophenylboronic acid pinacol ester; (3-Chloro-2,4-difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-(3-Chloro-2,4-difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol (3-Chloro-2,4-difluorophenyl)boronate; 3-Chloro-2,4-Difluorophenyl-Bpin; B-(3-Chloro-2,4-difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 3-Chloro-2,4-Difluorophenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.