Description

3-Bromo-5-(Trifluoromethoxy)Phenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable boronic ester derivative, serving as a critical building block in modern organic synthesis. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-quality intermediates for drug discovery and specialty chemical development.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing trifluoromethoxy and bromo substituents for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the unique halogenated aryl moiety can contribute to target specificity and environmental persistence.
• Material Science Research: Employed in the creation of organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge-transport layers, where its structure allows for fine-tuning of electronic properties.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands used in homogeneous catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and target engagement.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	3-Bromo-5-(Trifluoromethoxy)Phenylboronic Acid Pinacol Ester
CAS No.	1799485-18-9
Molecular Formula	C₁₃H₁₅BBrF₃O₃
Molecular Weight	366.97 g/mol
Synonyms	[3-Bromo-5-(trifluoromethoxy)phenyl]boronic acid pinacol ester; (3-Bromo-5-(trifluoromethoxy)phenyl)boronic acid pinacol ester; 2-[3-Bromo-5-(trifluoromethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Bromo-5-(trifluoromethoxy)benzeneboronic acid pinacol ester; Pinacol [3-bromo-5-(trifluoromethoxy)phenyl]boronate; B-[3-Bromo-5-(trifluoromethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Boronic acid, B-[3-bromo-5-(trifluoromethoxy)phenyl]-, pinacol ester
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-(Trifluoromethoxy)Phenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request. We are committed to meeting the stringent requirements of research and development as well as cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.