Description

n-Fmoc-n-Methyl-D-Aspartic Acid 4-tert-Butyl Ester is a high-purity, protected amino acid derivative designed for advanced peptide synthesis. This compound is critical for introducing a methylated aspartic acid residue with orthogonal protecting groups, enabling precise control over peptide chain assembly and modification. It is an essential building block for researchers and manufacturers in pharmaceutical development, particularly for creating complex peptide-based therapeutics, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the controlled incorporation of methylated aspartic acid into peptide sequences.
• Pharmaceutical Research & Development: Used in the synthesis of peptide drug candidates, including potential treatments for metabolic, neurological, and oncological disorders.
• Peptidomimetic Design: Serves as a precursor for creating modified peptides with enhanced stability, bioavailability, or receptor selectivity.
• Bioconjugation and Probe Synthesis: Facilitates the site-specific labeling of peptides with fluorophores, tags, or other functional molecules for diagnostic and imaging applications.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery.
• Academic and Institutional Research: Supports fundamental studies in biochemistry, medicinal chemistry, and chemical biology.

Basic Information

Item	Details
Product Name	n-Fmoc-n-Methyl-D-Aspartic Acid 4-tert-Butyl Ester
CAS No.	1799443-40-5
Molecular Formula	C25H29NO6
Molecular Weight	439.50 g/mol
Synonyms	Fmoc-N-Me-D-Asp(OtBu)-OH; (2R)-4-tert-Butyl 1-(9H-fluoren-9-ylmethoxycarbonyl)-2-methylamino-succinate; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-D-aspartic acid 4-tert-butyl ester; Fmoc-N-methyl-D-aspartic acid β-tert-butyl ester; N-Fmoc-N-methyl-D-aspartic acid 4-tert-butyl ester; Nα-Fmoc-Nα-methyl-D-aspartic acid 4-tert-butyl ester
EINECS	Contact for details

Quality Control

Every batch of n-Fmoc-n-Methyl-D-Aspartic Acid 4-tert-Butyl Ester is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with the high-purity standards required for pharmaceutical research and peptide synthesis. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (typically ≥98% by HPLC), and other critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.