Description

2,4-Difluoro-3-Trifluoromethylanisole is a high-value fluorinated aromatic building block, distinguished by its unique substitution pattern of fluorine and trifluoromethyl groups on an anisole core. This compound is engineered to provide exceptional reactivity and stability, making it a critical intermediate for the synthesis of advanced materials and active pharmaceutical ingredients (APIs). It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules where precise fluorination is required to modulate biological activity, lipophilicity, and metabolic stability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where the fluorine atoms enhance bioavailability and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, improving charge transport and thermal stability.
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart desired properties such as chemical resistance, low surface energy, and enhanced durability.
• Organic Synthesis & Catalysis: A versatile reagent in cross-coupling reactions and as a ligand precursor in organometallic catalysis for complex molecule assembly.
• Fluorine Chemistry Research: Essential reference standard and starting material for academic and industrial research exploring new fluorination methodologies and structure-activity relationships.

Basic Information

Item	Details
Product Name	2,4-Difluoro-3-Trifluoromethylanisole
CAS No.	1799420-90-8
Molecular Formula	C9H5F5O
Molecular Weight	224.13 g/mol
Synonyms	1,2-Difluoro-3-methoxy-5-(trifluoromethyl)benzene; 3-Methoxy-2,4-difluorobenzotrifluoride; 2,4-Difluoro-3-(trifluoromethyl)anisole; 2,4-Difluoro-α,α,α-trifluoro-3-methoxytoluene; Anisole, 2,4-difluoro-3-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 2,4-Difluoro-3-Trifluoromethylanisole is manufactured under strict quality management systems. We guarantee high purity levels, typically ≥97% (by GC/HPLC), and provide comprehensive analytical documentation. Our quality assurance protocol includes identity confirmation, purity assay, and control of key impurities to ensure batch-to-batch consistency and suitability for your synthetic applications. Certificates of Analysis (COA) are available upon request and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and heat sources. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.