Description

4-Defluoro-2-Fluoro Haloperidol Decanoate is a strategically modified derivative of the established antipsychotic agent haloperidol, designed for advanced pharmaceutical research and development. This compound is of significant interest for the synthesis of novel long-acting injectable (LAI) formulations and for probing structure-activity relationships (SAR) within the butyrophenone class. It serves as a critical pharmaceutical intermediate and reference standard for researchers in medicinal chemistry, process development, and analytical laboratories focused on neuropsychiatric therapeutics.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel haloperidol analogs and prodrugs for extended-release applications.
• Medicinal Chemistry Research: Used in SAR studies to investigate the impact of specific fluorine substitutions on receptor binding affinity, metabolic stability, and pharmacokinetic profiles.
• Reference Standard: Serves as a high-purity certified material for analytical method development, validation, and quality control in API manufacturing.
• Process Development: Employed in route scouting and optimization for the production of next-generation long-acting injectable (LAI) antipsychotics.
• Preclinical Studies: Utilized in the development and evaluation of new drug delivery systems and formulations.

Basic Information

Product Name	4-Defluoro-2-Fluoro Haloperidol Decanoate
CAS No.	1798004-21-3
Molecular Formula	C31H40ClF2NO3
Molecular Weight	548.11 g/mol
Synonyms	2-Fluoro-4-defluorohaloperidol decanoate; Haloperidol Decanoate Impurity; Haloperidol Decanoate Related Compound; 1-(4-Chlorophenyl)-4-[4-(2-fluorophenyl)-4-oxobutyl]piperidin-1-ium-1-yl decanoate; 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidyl]-1-(2-fluorophenyl)-butan-1-one decanoate ester; Fluorinated Haloperidol Decanoate Derivative; LAI Haloperidol Analog Intermediate
EINECS	Contact for details

Quality Control

Our 4-Defluoro-2-Fluoro Haloperidol Decanoate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) that document all critical quality attributes, supporting your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. For long-term storage, consider storing under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.