Description

Acyclovir n-Methylene Dimer is a high-purity pharmaceutical intermediate, specifically a dimeric derivative of the antiviral drug acyclovir. This compound is critical for advanced research and development in antiviral drug discovery and process chemistry. It serves as a key building block for medicinal chemists and pharmaceutical manufacturers focused on developing next-generation antiviral therapies and exploring novel prodrug strategies.

Application

• Pharmaceutical Intermediate: Primary use as a sophisticated building block in the synthesis of novel antiviral agents and prodrugs.
• Antiviral Research: Enables structure-activity relationship (SAR) studies to develop new analogs with improved efficacy or pharmacokinetic profiles.
• Process Chemistry: Used in route scouting and optimization for the scalable production of acyclovir-related active pharmaceutical ingredients (APIs).
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.
• Academic Research: A valuable tool for universities and research institutes studying nucleoside chemistry and antiviral mechanisms of action.
• Bioconjugation Studies: Potential use in linker chemistry for creating targeted drug delivery systems due to its dimeric structure.

Basic Information

Product Name	Acyclovir n-Methylene Dimer
CAS No.	1797131-64-6
Molecular Formula	C18H26N10O6
Molecular Weight	478.47 g/mol
Synonyms	9-[(2-Hydroxyethoxy)methyl]guanine n-Methylene Dimer; Acyclovir Dimer; Acyclovir Methylene Dimer; Bis(acyclovir) Methylene Ether; 2-Amino-1,9-dihydro-9-[[2-(hydroxymethoxy)ethyl]methyl]methyl]-6H-purin-6-one Dimer; ACV Dimer
EINECS	Contact for details

Quality Control

Our Acyclovir n-Methylene Dimer is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. We provide Certificates of Analysis (COA) with each shipment to ensure full traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.