Description

(R)-Tamsulosin-D3 Hydrochloride is a deuterium-labeled isotopologue of the active pharmaceutical ingredient (R)-Tamsulosin, a selective α-1A adrenergic receptor antagonist. This high-purity reference standard is critical for ensuring the accuracy and reliability of pharmacokinetic, metabolic, and bioanalytical studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug development and quality control.

Application

• Internal Standard for Quantitative Bioanalysis: Serves as a stable isotope-labeled internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) methods for the precise quantification of Tamsulosin in biological matrices like plasma and urine.
• Metabolite Identification and Pathway Studies: Used in drug metabolism and pharmacokinetics (DMPK) research to trace and identify metabolites, facilitating a deeper understanding of the drug's biotransformation pathways.
• Method Development and Validation: Essential for developing, optimizing, and validating robust analytical methods in compliance with regulatory guidelines (e.g., FDA, ICH).
• Pharmacokinetic/Pharmacodynamic (PK/PD) Modeling: Enables accurate measurement of drug concentration over time, supporting critical PK/PD analyses during clinical and non-clinical studies.
• Quality Control and Reference Standard: Acts as a certified reference material (CRM) for the quality control of (R)-Tamsulosin HCl active pharmaceutical ingredient (API) and finished dosage forms.
• Stability-Indicating Assays: Employed in stability testing to monitor the integrity and degradation of Tamsulosin under various stress conditions.

Basic Information

Product Name	(R)-Tamsulosin-D3 Hydrochloride
CAS No.	1795787-12-0
Molecular Formula	C₂₀H₂₅D₃N₂O₅S • HCl
Molecular Weight	445.99 g/mol (for monoisotopic mass)
Synonyms	(R)-5-[2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide-d3 Hydrochloride; (R)-Tamsulosin-d3 HCl; Deuterated (R)-Tamsulosin Hydrochloride; (R)-YM12617-d3 Hydrochloride; (R)-Flomax-d3 Hydrochloride; (R)-Omnic-d3 Hydrochloride; (R)-Tamsulosin (methyl-d3) Hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-Tamsulosin-D3 Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for chemical and isotopic purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing batch-specific results are provided to ensure traceability and compliance with the stringent requirements of pharmaceutical reference standard applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This compound is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 99.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.