Description

(R)-(+)-Verapamil-D6 Hydrochloride is a high-purity, deuterium-labeled isotopologue of the classic calcium channel blocker, verapamil hydrochloride. This compound is specifically designed for use as an internal standard in quantitative bioanalytical methods, ensuring superior accuracy and reliability in pharmacokinetic and metabolic studies. It is an essential tool for pharmaceutical R&D, contract research organizations (CROs), and analytical laboratories focused on cardiovascular drug development and ADME (Absorption, Distribution, Metabolism, and Excretion) profiling.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable, non-interfering internal standard for the precise quantification of verapamil and its metabolites in complex biological matrices like plasma, serum, and tissue homogenates.
• Pharmacokinetic (PK) Studies: Enables accurate tracking of drug concentration over time, critical for determining bioavailability, half-life, and clearance rates in preclinical and clinical trials.
• Drug Metabolism Research: Used in mass spectrometry to study metabolic pathways and identify metabolites, aiding in the understanding of a drug's biotransformation.
• Bioequivalence Testing: Supports rigorous analytical testing required to demonstrate therapeutic equivalence between generic and brand-name drug formulations.
• Forensic Toxicology: Assists in the accurate identification and quantification of verapamil in forensic investigations.
• Quality Control in Manufacturing: Can be utilized in analytical method development and validation within pharmaceutical quality control laboratories.

Basic Information

Product Name	(R)-(+)-Verapamil-D6 Hydrochloride
CAS No.	1795786-09-2
Molecular Formula	C27H32D6ClN2O4 • HCl
Molecular Weight	~ 507.1 g/mol (for monohydrochloride)
Synonyms	(+)-(R)-Verapamil-d6 hydrochloride; (R)-Verapamil-d6 HCl; 5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile-d6 hydrochloride; α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzenecetonitrile-d6 hydrochloride; Isotopically Labeled Verapamil Internal Standard; Verapamil D6 HCl.
EINECS	Contact for details

Quality Control

Every batch of (R)-(+)-Verapamil-D6 Hydrochloride is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and isotopic enrichment meet the stringent requirements for mass spectrometry applications. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results for assay, isotopic purity (D6 content), chromatographic purity, and residual solvents. Our quality system is designed to support GMP/GLP-compliant research and development.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccant in the container.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D6)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.