Description

5-[[4-(2-Cyclohexylethoxy)-3-Methoxyphenyl]Methylene]-2,4-Thiazolidinedione-D4 is a deuterated analog of a thiazolidinedione derivative, a class of compounds with significant research interest. This stable isotope-labeled compound is essential for precise analytical and metabolic studies, providing critical data for pharmacokinetic and pharmacodynamic modeling. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and analytical laboratories engaged in the development of novel therapeutic agents.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a critical reference standard in quantitative bioanalytical methods for drug discovery and development.
• Metabolic Pathway Tracing: Used in mass spectrometry-based studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profiles of its non-deuterated counterpart.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradation products during drug substance development.
• Preclinical and Clinical Research: Supports pharmacokinetic (PK) and pharmacodynamic (PD) studies to ensure accurate and reliable data generation.
• Stable Isotope Dilution Assays: Enables highly accurate quantification in complex biological matrices, minimizing matrix effects.
• Chemical Reference Material: Provides a certified standard for method validation and quality control in analytical laboratories.

Basic Information

Product Name	5-[[4-(2-Cyclohexylethoxy)-3-Methoxyphenyl]Methylene]-2,4-Thiazolidinedione-D4
CAS No.	1795143-97-3
Molecular Formula	C19H21D4NO4S
Molecular Weight	367.50 g/mol (approx.)
Synonyms	5-[[4-(2-Cyclohexylethoxy)-3-methoxyphenyl]methylene]-2,4-thiazolidinedione-d4; Deuterated Ciglitzone derivative; 2,4-Thiazolidinedione, 5-[[4-(2-cyclohexylethoxy)-3-methoxyphenyl]methylene]-d4; [phenyl-D4]-5-[[4-(2-cyclohexylethoxy)-3-methoxyphenyl]methylene]thiazolidine-2,4-dione; Stable Isotope Labeled Thiazolidinedione; Ciglitzone-d4; CAS 1795143-97-3
EINECS	Contact for details

Quality Control

Every batch of our deuterated compounds is produced and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity verified by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and LC-MS. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, isotopic enrichment, and analytical results. Our quality commitment ensures compliance with the stringent requirements of pharmaceutical R&D and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C. Keep the container sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Off-white to yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (LC-MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.