Description

n-Desmethyl-4'-Hydroxy Tamoxifen-D3 (E/Z Mixture) is a deuterated analog of a key tamoxifen metabolite, designed for use as a high-purity internal standard in analytical chemistry. This compound is critical for ensuring accurate quantification and method validation in complex biological matrices, addressing the core need for reliability and precision in pharmaceutical research. It is primarily utilized by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in bioanalytical method development, pharmacokinetic studies, and drug metabolism research for selective estrogen receptor modulators (SERMs).

Application

• Bioanalytical Internal Standard: Serves as a stable isotope-labeled internal standard for the precise quantification of tamoxifen and its metabolites in biological samples (e.g., plasma, serum, tissue) via LC-MS/MS.
• Pharmacokinetic (PK) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Metabolite Profiling & Identification: Aids in the structural elucidation and quantification of tamoxifen-related metabolites in drug metabolism and pharmacodynamics (DMPK) studies.
• Method Development & Validation: Used as a critical reference material to develop, optimize, and validate robust analytical methods, ensuring regulatory compliance (e.g., FDA, EMA guidelines).
• Quality Control in Manufacturing: Supports impurity profiling and quality assurance processes in the production of active pharmaceutical ingredients (APIs) and finished drug products.
• Forensic & Doping Analysis: Applied in specialized testing laboratories for the detection and confirmation of tamoxifen and its derivatives.

Basic Information

Product Name	n-Desmethyl-4'-Hydroxy Tamoxifen-D3 (E/Z Mixture)
CAS No.	1795139-22-8
Molecular Formula	C25H26D3NO2
Molecular Weight	~ 379.55 g/mol
Synonyms	(Z)-4-Hydroxy-N-desmethyltamoxifen-d3; (E)-4-Hydroxy-N-desmethyltamoxifen-d3; 4-Hydroxyendoxifen-d3; Endoxifen Metabolite-d3; 1-[4-[2-(Dimethylamino)ethoxy]phenyl]-1,2-diphenyl-1-buten-3-yl-d3-4-ol; 4-OH-N-desmethyltamoxifen-d3; Deuterated 4-Hydroxy-N-desmethyltamoxifen
EINECS	Contact for details

Quality Control

Our n-Desmethyl-4'-Hydroxy Tamoxifen-D3 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and isotopic enrichment, NMR for structural confirmation, and mass spectrometry for identity verification. We provide comprehensive Certificates of Analysis (COA) detailing all specifications, ensuring the material meets the stringent requirements for use as a certified reference standard in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation. For long-term stability, store desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0% (sum of E/Z isomers)
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Isomer Ratio (E/Z)	Specified on COA
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.