Description

Clavulanic Acid Imidazole Derivative - Labeled D3 is a deuterium-labeled analog of a key clavulanic acid intermediate, specifically designed for advanced research and development. This compound is essential for use as an internal standard in mass spectrometry, enabling precise quantification and metabolic studies in complex biological matrices. It is primarily utilized by pharmaceutical R&D laboratories, analytical chemists, and contract research organizations (CROs) focused on antibiotic development, pharmacokinetics, and bioanalytical method validation.

Application

• Internal Standard for LC-MS/MS: Critical for the accurate quantification of clavulanic acid and related metabolites in pharmacokinetic and bioequivalence studies.
• Metabolic Pathway Tracing: Used in drug metabolism and disposition (DMPK) research to elucidate metabolic pathways and identify metabolites.
• Bioanalytical Method Development: Serves as a stable isotope-labeled reference material for developing and validating robust HPLC and mass spectrometry assays.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradation products in β-lactamase inhibitor formulations.
• Clinical Research Support: Provides reliable data for clinical trials involving β-lactam antibiotic combinations.
• Quality Control in API Manufacturing: Supports high-purity analysis in the production of clavulanate potassium and other related active pharmaceutical ingredients (APIs).

Basic Information

Item	Details
Product Name	Clavulanic Acid Imidazole Derivative - Labeled D3
CAS No.	1795138-51-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Clavulanic Acid D3-Imidazole Derivative; Deuterated Clavulanic Acid Imidazole Ester; [D3]-Clavulanic Acid Imidazole Derivative; Clavulanate Imidazole Derivative-d3; Internal Standard for Clavulanic Acid (D3-labeled); CAS 1795138-51-0; (2R,3Z,5R)-3-(2-Hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid Imidazole Derivative (D3)
EINECS	Contact for details

Quality Control

Every batch of our Clavulanic Acid Imidazole Derivative - Labeled D3 is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, with comprehensive characterization using NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (HPLC), isotopic enrichment (D3 content), and other critical specifications to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant and inert atmosphere to maintain stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Isotopic Purity (D3)	≥ 98.0 atom % D
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.