Description

Cloranolol-D9 is a deuterium-labeled isotopologue of the β-adrenergic receptor antagonist cloranolol, identified by CAS number 1795031-39-8. This high-purity stable isotope-labeled compound serves as a critical internal standard in quantitative bioanalytical methods, ensuring unparalleled accuracy and reliability in pharmacokinetic and metabolic studies. It is an essential tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in advanced drug development and regulatory submission support.

Application

• Bioanalytical Internal Standard: Primary use as a deuterated internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the precise quantification of cloranolol and its metabolites in biological matrices like plasma, serum, and urine.
• Pharmacokinetic & Metabolism Studies: Enables accurate determination of absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Drug Development & Validation: Supports method development and validation for regulatory compliance (FDA, EMA) in new drug applications (NDAs).
• Doping Control Analysis: Used in forensic and sports anti-doping laboratories for the sensitive and confirmatory detection of β-blockers.
• Metabolite Identification: Aids in the structural elucidation of drug metabolites using mass spectrometry.
• Quality Control in Reference Material Production: Serves as a calibrant or reference compound for ensuring the quality of certified reference materials (CRMs).

Basic Information

Product Name	Cloranolol-D9
CAS No.	1795031-39-8
Molecular Formula	C16H14D9ClN2O3
Molecular Weight	Approx. 323.8 g/mol (Contact for exact value)
Synonyms	1-(2-Chloro-5-methylphenoxy)-3-[(1,1-dimethylethyl)amino]-2-propanol-d9; Cloranolol (phenyl-d5, tert-butyl-d4); [D9]-Cloranolol; Cloranolol-d9 (deuterated); 3-(tert-Butyl-d9-amino)-1-(2-chloro-5-methylphenoxy)-2-propanol; Deuterated Cloranolol; Cloranolol Internal Standard
EINECS	Contact for details

Quality Control

Every batch of Cloranolol-D9 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, verified by advanced spectroscopic and chromatographic techniques including NMR, HPLC, and LC-MS. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, isotopic enrichment, and analytical results. Our quality commitment ensures consistency for your most demanding research and regulatory applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (NMR/LC-MS)	≥ 98.0 atom % D
Chemical Purity (Titration)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.