Description

Desloratadine-D7 (Major) is a deuterium-labeled analog of the active pharmaceutical ingredient desloratadine, specifically designed for use as an internal standard in quantitative bioanalytical studies. This high-purity, isotopically enriched compound is critical for ensuring the accuracy and reliability of mass spectrometry-based assays, particularly in pharmacokinetic and metabolism research. It is an essential tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers focused on developing and validating methods for the antihistamine desloratadine and its metabolites.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable, non-interfering internal standard for the precise quantification of desloratadine in complex biological matrices like plasma, serum, and urine.
• Pharmacokinetic (PK) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in clinical and pre-clinical trials.
• Bioanalytical Method Development & Validation: Serves as a critical reference material for developing robust, sensitive, and specific HPLC-MS/MS methods compliant with FDA and ICH guidelines.
• Drug Metabolism Research: Used in metabolite identification and profiling studies to understand the biotransformation pathways of desloratadine.
• Quality Control in Pharmaceutical Analysis: Supports in-process testing and quality assurance of desloratadine in finished drug products.
• Forensic and Doping Control Analysis: Facilitates the accurate detection and quantification of desloratadine in forensic toxicology and anti-doping programs.

Basic Information

Product Name	Desloratadine-D7 (Major)
CAS No.	1795024-82-6
Molecular Formula	C19H12D7ClN2
Molecular Weight	314.86 g/mol
Synonyms	8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine-d7; Desloratadine (phenyl-d5, pyridine-d2); Descarboethoxyloratadine-d7; Clarinex-d7; Aerius-d7; Neoclarityn-d7; Azomyr-d7; [D7]-Desloratadine
EINECS	Contact for details

Quality Control

Our Desloratadine-D7 (Major) is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for sensitive analytical applications. Each lot undergoes comprehensive testing, including isotopic purity (D-enrichment) determination by NMR and MS, chemical purity assessment by HPLC, and confirmation of structure by spectroscopic methods. A comprehensive Certificate of Analysis (COA) detailing all test results, including assay, isotopic enrichment, and impurity profile, is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.