Description

Defluoro Prasugrel-D5 Hydrochloride is a deuterium-labeled internal standard of a key pharmaceutical intermediate, specifically designed for high-precision analytical applications. This compound is critical for ensuring the accuracy and reliability of quantitative bioanalytical methods, such as LC-MS/MS, in drug metabolism and pharmacokinetic (DMPK) studies. It is an essential tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and quality control units requiring definitive quantification of Prasugrel and its metabolites.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard for the precise quantification of Prasugrel and its metabolites in biological matrices (plasma, serum, urine) using LC-MS/MS.
• Drug Metabolism & Pharmacokinetics (DMPK): Enables accurate studies of absorption, distribution, metabolism, and excretion (ADME) for the antiplatelet agent Prasugrel.
• Clinical Trial Support: Used in the bioanalytical method development and validation supporting Phase I-IV clinical trials to ensure data integrity.
• Pharmaceutical Quality Control: Supports impurity profiling and stability testing of active pharmaceutical ingredients (APIs) and finished drug products.
• Forensic & Toxicological Analysis: Aids in the specific detection and measurement of Prasugrel in forensic investigations or overdose cases.
• Reference Standard Manufacturing: Acts as a high-purity starting material or calibration standard for certified reference material (CRM) producers.

Basic Information

Item	Detail
Product Name	Defluoro Prasugrel-D5 Hydrochloride
CAS No.	1794964-35-4
Molecular Formula	C20H15D5FNO3S • HCl
Molecular Weight	~ 424.96 g/mol (as hydrochloride salt)
Synonyms	Prasugrel-d5 Hydrochloride; 5-[2-Cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl Acetate-d5 Hydrochloride; (RS)-5-(2-Cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate-d5 hydrochloride; Defluoro Prasugrel D5 HCl; Prasugrel Internal Standard D5; LY640315-d5 Hydrochloride; Effient-d5 Hydrochloride (deuterated)
EINECS	Contact for details

Quality Control

Every batch of Defluoro Prasugrel-D5 Hydrochloride is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure it meets the stringent requirements for an isotopic internal standard. Our quality protocols are designed to guarantee high chemical and isotopic purity, along with structural identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), isotopic enrichment (by MS), and identification data is provided with each shipment to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a dry environment. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D5)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.