Description

(+)3,4-Dichloro-α-[[[(3-Methoxyphenyl)Methyl]Methylamino]Methyl]-Benzenemethanol-D3 is a high-purity, deuterated chemical intermediate of significant importance in advanced pharmaceutical research and development. This compound matters because its deuterium-labeled structure is specifically designed to alter metabolic pathways and improve the pharmacokinetic profiles of drug candidates, a key strategy in modern medicinal chemistry. It is primarily needed by pharmaceutical companies and contract research organizations (CROs) engaged in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for applications in metabolic studies, bioanalytical method development, and as an internal standard for mass spectrometry.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of deuterated drug candidates targeting enhanced metabolic stability and reduced toxicity.
• Metabolic Tracer: Used in drug metabolism and pharmacokinetics (DMPK) studies to track and quantify metabolic pathways in preclinical research.
• Internal Standard for LC-MS/MS: Serves as a high-purity, isotopically labeled internal standard in quantitative bioanalytical assays, ensuring accurate and reliable data.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies by investigating the isotope effect of deuterium substitution on biological activity.
• Reference Standard: Provides a certified reference material for quality control and regulatory submissions in drug development pipelines.
• Preclinical Development: Supports formulation studies and early-stage toxicology assessments of new chemical entities (NCEs).

Basic Information

Product Name	(+)3,4-Dichloro-α-[[[(3-Methoxyphenyl)Methyl]Methylamino]Methyl]-Benzenemethanol-D3
CAS No.	1794892-13-9
Molecular Formula	C17H18D3Cl2NO2
Molecular Weight	~347.3 g/mol (deuterated)
Synonyms	(+)-3,4-Dichloro-α-(((3-methoxybenzyl)methylamino)methyl)benzenemethanol-d3; Benzenemethanol, 3,4-dichloro-α-[[[(3-methoxyphenyl)methyl]methylamino]methyl]-, (αR)-, 3,4,5-trideuterio; Deuterated Levomilnacipran Intermediate; (R)-3,4-Dichloro-α-((((3-methoxybenzyl)methylamino)methyl)benzenemethanol-d3; D3-Labelled Benzyl Alcohol Derivative; Isotopically Labeled Adrenergic Compound; Research Compound 1794892-13-9
EINECS	Contact for details

Quality Control

Our (+)3,4-Dichloro-α-[[[(3-Methoxyphenyl)Methyl]Methylamino]Methyl]-Benzenemethanol-D3 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical and isotopic purity, consistent with standards for pharmaceutical research. Comprehensive Certificates of Analysis (COA) are provided, detailing results for assay, chiral purity, deuterium enrichment, and impurity profiles via techniques such as HPLC, NMR, and MS. We support compliance with cGMP and ICH Q7 guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to maintain stability. Keep the container tightly sealed when not in use to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Deuterium Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.