Description

(±)-Bopindolol-D9 is a deuterated isotopologue of the non-selective β-adrenergic antagonist bopindolol, where nine hydrogen atoms are replaced with deuterium. This compound is a critical internal standard for the precise quantification of bopindolol in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is an essential tool for researchers and quality control laboratories in the pharmaceutical and contract research organization (CRO) sectors, enabling accurate pharmacokinetic studies, drug metabolism research, and bioanalytical method development.

Application

• Bioanalytical Reference Standard: Serves as a stable isotope-labeled internal standard (SIL-IS) for the accurate quantification of bopindolol in plasma, serum, and urine via mass spectrometry.
• Pharmacokinetic & Metabolism Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Method Development & Validation: Used to develop, optimize, and validate robust LC-MS/MS methods for regulatory compliance in drug development.
• Pharmaceutical Quality Control: Supports impurity profiling and assay development for bopindolol-containing drug products.
• Forensic & Doping Analysis: Aids in the detection and confirmation of bopindolol in forensic toxicology and anti-doping control programs.

Basic Information

Product Name	(±)-Bopindolol-D9
CAS No.	1794891-82-9
Molecular Formula	C23H26D9N3O3
Molecular Weight	~407.6 g/mol
Synonyms	Bopindolol-d9; 1-[(1,1-Dimethylethyl)amino]-3-[(2-methyl-1H-indol-4-yl)oxy]-2-propanol-d9; 4-[2-[(tert-Butylamino)-1-hydroxyethyl]-2-methyl-1H-indol-3-yl]oxy-d9; (±)-1-(tert-Butylamino)-3-[(2-methyl-1H-indol-4-yl)oxy]-2-propanol-d9; 4-[3-(tert-Butylamino)-2-hydroxypropoxy]-2-methyl-1H-indol-d9; Bopindolol (phenyl-d9); Bopindolol D9; Bopindolol-d9 Isotope
EINECS	Contact for details

Quality Control

Our (±)-Bopindolol-D9 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic methods, including NMR, HPLC, and mass spectrometry, to confirm identity, chemical purity, and deuterium enrichment. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, consider storage under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (Deuterium Enrichment)	≥98 atom % D
Chemical Purity	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.