Description

Cyclopentyl 3-[2-Methoxy-4-[p-(Tolyl-D7)Sulfonylcarbamoyl)Benzyl]-1-Methylindol-5-Ylcarbamate is a high-purity, deuterated chemical intermediate of significant importance in advanced pharmaceutical research and development. This compound is specifically designed for use in metabolic and pharmacokinetic studies, where its deuterium-labeled structure provides critical analytical advantages. It is an essential building block for medicinal chemists and analytical scientists working in drug discovery, particularly for the development of novel indole-based therapeutics targeting central nervous system and oncological pathways.

Application

• Pharmaceutical Intermediate: A key deuterated synthon in the multi-step synthesis of novel drug candidates, especially those with indole scaffolds.
• Metabolic Tracer: Used in Drug Metabolism and Pharmacokinetics (DMPK) studies to track and quantify drug metabolites using advanced techniques like LC-MS/MS.
• Internal Standard for Bioanalysis: Serves as a high-quality, stable isotope-labeled internal standard (SIL-IS) to ensure accuracy and precision in quantitative bioanalytical assays.
• Proteomics & Biomarker Research: Employed in chemical proteomics for activity-based protein profiling and the discovery of new biological targets.
• Medicinal Chemistry Research: Facilitates structure-activity relationship (SAR) studies by providing a labeled analog to investigate the impact of molecular modifications.
• Reference Standard: Used as a certified reference material (CRM) for method development and validation in regulatory-compliant laboratories.

Basic Information

Product Name	Cyclopentyl 3-[2-Methoxy-4-[p-(Tolyl-D7)Sulfonylcarbamoyl)Benzyl]-1-Methylindol-5-Ylcarbamate
CAS No.	1794886-13-7
Molecular Formula	C31H26D7N3O6S
Molecular Weight	~584.72 g/mol
Synonyms	Deuterated Tolyl Indole Carbamate; 5-(Cyclopentyloxycarbonylamino)-1-methyl-2-methoxy-4-[[[4-(methyl-d7)phenyl]sulfonyl]aminocarbonyl]methyl]indole; 1-Methyl-5-[(cyclopentyloxy)carbonyl]amino-2-methoxy-4-[[[[4-(methyl-d7)phenyl]sulfonyl]amino]carbonyl]methyl]indole; CAS 1794886-13-7; Deuterated Sulfonylcarbamoyl Indole Derivative; (Tolyl-D7)Sulfonylcarbamoyl Benzyl Indole Carbamate
EINECS	Contact for details

Quality Control

This high-value intermediate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and purity suitable for sensitive research applications. Our quality system emphasizes isotopic purity (D7 content) and chemical purity as critical parameters. Comprehensive testing includes HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each batch, documenting identity, purity (typically ≥95% by HPLC), isotopic enrichment, and impurity profile.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Isotopic Purity (D7 content, MS)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.