Description

Tandospirone-D8 CAS NO 1794835-73-6 is a deuterated analog of the anxiolytic drug tandospirone, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity, isotopically labeled compound is critical for ensuring accuracy and reliability in mass spectrometry-based analyses, such as LC-MS/MS. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and forensic toxicology labs for method development, validation, and precise quantification of tandospirone in complex biological matrices.

Application

• Internal Standard for Bioanalysis: Essential for the accurate quantification of tandospirone in pharmacokinetic (PK) and pharmacodynamic (PD) studies using LC-MS/MS.
• Drug Metabolism and Disposition Research: Used to track and quantify drug metabolites in in vitro and in vivo studies, aiding in ADME (Absorption, Distribution, Metabolism, Excretion) profiling.
• Forensic and Clinical Toxicology: Enables precise measurement of tandospirone levels in blood, plasma, or urine samples for forensic investigations or therapeutic drug monitoring.
• Pharmaceutical Quality Control: Serves as a reference standard in the development and validation of analytical methods for drug substance and product testing.
• Stable Isotope Labeling Studies: Facilitates research into metabolic pathways and the environmental fate of pharmaceutical compounds.

Basic Information

Product Name	Tandospirone-D8
CAS No.	1794835-73-6
Molecular Formula	C21H21D8N5O2
Molecular Weight	383.53 g/mol
Synonyms	Deuterated Tandospirone; Tandospirone (hexadeutero); SM-3997-D8; 3aa,4b,7b,7aa-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dione-d8; Metanopirone-D8; Sediel-D8
EINECS	Contact for details

Quality Control

Our Tandospirone-D8 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR and Mass Spectrometry for structural confirmation and isotopic enrichment verification, and HPLC for chemical and isotopic purity assessment. Certificates of Analysis (COA) detailing batch-specific results are provided to ensure traceability and compliance with your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 99.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.