Description

o-Desmethyl Felodipine-D5 is a deuterium-labeled internal standard critical for accurate quantitative analysis in bioanalytical studies. This high-purity compound is essential for ensuring precision and reliability in mass spectrometry-based assays, particularly for pharmacokinetic and metabolism research. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers working with the calcium channel blocker felodipine.

Application

• Primary use as an internal standard for the quantification of felodipine and its metabolites in biological matrices via LC-MS/MS and GC-MS.
• Supporting pharmacokinetic (PK) and bioequivalence studies in drug development and clinical trials.
• Enabling precise drug metabolism and disposition (DMPK) research for felodipine.
• Critical component in regulated bioanalysis for method development and validation under GLP guidelines.
• Used in forensic and doping control analysis for accurate substance identification and quantification.
• Application in environmental fate studies tracking pharmaceutical residues.

Basic Information

Product Name	o-Desmethyl Felodipine-D5
CAS No.	1794827-40-9
Molecular Formula	C18H14D5Cl2NO4
Molecular Weight	~387.27 g/mol
Synonyms	Felodipine Impurity D5; Felodipine-d5 Metabolite; Deuterated o-Desmethyl Felodipine; 2,6-Dimethyl-4-(2,3-dichlorophenyl)-1,4-dihydro-3,5-pyridinedicarboxylic Acid 5-(2-Methoxyethyl) Methyl-d5 Ester; Felodipine Related Compound D5; Felodipine-d5 Derivative; Internal Standard for Felodipine
EINECS	Contact for details

Quality Control

Every batch of o-Desmethyl Felodipine-D5 is manufactured and tested to meet the stringent requirements for deuterated internal standards. Our quality assurance includes rigorous analytical testing by HPLC, NMR, and MS to ensure high chemical and isotopic purity. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific results for identity, purity, and isotopic enrichment. We support compliance with GLP and cGMP standards for research and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (D5)	≥98.0 atom % D
Chemical Purity (by NMR)	Conforms
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.