Description

3-Cyclopropylmethoxy-4-Difluoromethoxybenzoic-D4 Acid is a deuterated derivative of a key benzoic acid-based intermediate, offering a stable isotopic label for advanced research and development. This compound is specifically engineered for use in metabolic and pharmacokinetic studies, providing critical insights into drug disposition and mechanism of action. It is an essential building block for pharmaceutical chemists and researchers in the life sciences sector, particularly those developing and analyzing novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Serves as a certified internal standard for the precise quantification of its non-deuterated counterpart in bioanalytical methods using LC-MS/MS.
• Metabolic Tracer Studies: Utilized in drug metabolism and pharmacokinetics (DMPK) research to track the absorption, distribution, metabolism, and excretion (ADME) of lead compounds.
• Active Pharmaceutical Ingredient (API) Intermediate: Acts as a deuterated synthon in the synthesis of isotopically labeled drug candidates, potentially enhancing metabolic stability.
• Mechanistic Research: Employed in biochemical and pharmacological studies to elucidate reaction pathways and enzyme mechanisms without interference from background signals.
• Diagnostic Agent Development: Used in the research and development of novel diagnostic imaging agents and probes for positron emission tomography (PET) or other imaging modalities.

Basic Information

Item	Details
Product Name	3-Cyclopropylmethoxy-4-Difluoromethoxybenzoic-D4 Acid
CAS No.	1794816-96-8
Molecular Formula	C12H8D4F2O4
Molecular Weight	258.23 g/mol (approx.)
Synonyms	3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic-2,3,5,6-d4 Acid; Benzoic-2,3,5,6-d4 Acid, 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-; Deuterated 3-CPM-4-DFMB Acid; [2,3,5,6-2H4]-3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid; Isotopically Labeled Benzoic Acid Derivative; D4-3-Cyclopropylmethoxy-4-difluoromethoxybenzoic Acid
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality-controlled environments to ensure isotopic purity and chemical integrity. Each batch is analyzed using advanced spectroscopic and chromatographic techniques, including NMR and HPLC-MS, to confirm deuterium incorporation and chemical purity. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing assay, isotopic enrichment, and impurity profiles to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.