Description

3-Diethylamino Acetaminophen-D10 is a deuterated analog of a key pharmaceutical intermediate, specifically designed for advanced research and development applications. This high-purity compound is essential for studies requiring internal standards in mass spectrometry, enabling precise quantification and metabolic pathway analysis. It is primarily utilized by pharmaceutical R&D laboratories, analytical service providers, and manufacturers of diagnostic reagents for applications in drug metabolism and pharmacokinetics (DMPK) research.

Application

• Internal Standard for LC-MS/MS: Serves as a critical deuterated internal standard for the accurate quantification of its non-deuterated counterpart in bioanalytical methods.
• Drug Metabolism Studies (DMPK): Used in pharmaceutical R&D to trace metabolic pathways, study bioavailability, and perform pharmacokinetic profiling with high specificity.
• Analytical Reference Standard: Provides a certified reference material for method development, validation, and quality control in analytical laboratories.
• Isotope Dilution Mass Spectrometry (IDMS): Enables highly accurate and precise measurements in complex biological matrices through isotope dilution techniques.
• Diagnostic Reagent Manufacturing: Employed in the synthesis of reagents for clinical diagnostic assays requiring high specificity and low background interference.

Basic Information

Product Name	3-Diethylamino Acetaminophen-D10
CAS No.	1794789-22-2
Molecular Formula	C12H9D10N2O2
Molecular Weight	229.33 g/mol (approximate)
Synonyms	N-(4-Hydroxyphenyl)-N,N-diethylacetamide-d10; 4'-Hydroxyacetanilide-d10, Diethylamino-; Deuterated 3-Diethylaminoacetaminophen; Acetaminophen Diethylamino-d10; Diethylamino Deuterated Paracetamol; [D10]-3-Diethylaminoacetaminophen; 3-(Diethylamino)acetaminophen-d10; N-Acetyl-p-aminophenol Diethylamino-d10 Derivative
EINECS	Contact for details

Quality Control

Our 3-Diethylamino Acetaminophen-D10 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high isotopic purity. Each lot undergoes comprehensive analysis including HPLC for chemical purity and NMR/MS for confirmation of structure and deuterium enrichment. A detailed Certificate of Analysis (COA) is provided, documenting specifications for assay, isotopic purity, and residual solvents in compliance with relevant ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content, MS)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.