Description

n-(2,6-Dimethylphenyl)-4-(2-Hydroxy-3-Phenoxypropyl)-1-Piperazineacetamide-D5 is a deuterated analog of a key pharmaceutical intermediate, offering enhanced stability and utility in advanced research and development. This compound is critical for conducting precise metabolic and pharmacokinetic studies, providing superior analytical sensitivity and data integrity. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers focused on developing and validating novel therapeutic agents.

Application

• As a stable isotope-labeled internal standard for the quantitative analysis of its non-deuterated counterpart in biological matrices using LC-MS/MS.
• For conducting advanced pharmacokinetic (PK) and drug metabolism studies in pharmaceutical research and development.
• Use in deuterium exchange experiments and mechanistic studies to understand metabolic pathways.
• Critical material for the development and validation of bioanalytical methods in compliance with GLP and FDA guidelines.
• Application in isotope dilution mass spectrometry to achieve high-precision and accurate quantification.
• As a reference compound in quality control and assurance for the production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	n-(2,6-Dimethylphenyl)-4-(2-Hydroxy-3-Phenoxypropyl)-1-Piperazineacetamide-D5
CAS No.	1794788-57-0
Molecular Formula	C23H26D5N3O3
Molecular Weight	~403.56 g/mol
Synonyms	4-(2-Hydroxy-3-phenoxypropyl)-N-(2,6-dimethylphenyl)-1-piperazineacetamide-d5; Deuterated Carvedilol Impurity/Intermediate; Carvedilol-d5 (deuterated analog); 1-Piperazineacetamide, N-(2,6-dimethylphenyl)-4-(2-hydroxy-3-phenoxypropyl)-, deuterated; BM-14190-d5; SKF-105517-d5; (RS)-1-(Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol-d5 (related deuterated structure)
EINECS	Contact for details

Quality Control

Every batch of n-(2,6-Dimethylphenyl)-4-(2-Hydroxy-3-Phenoxypropyl)-1-Piperazineacetamide-D5 is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing performed using advanced techniques like NMR, HPLC, and Mass Spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (HPLC), isotopic enrichment (D-content), and other critical parameters to meet the stringent requirements of pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider keeping the material under inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.