Description

4-[5-(3-Fluoro-4-Methoxyphenyl)-3-(Difluoromethyl)-1H-Pyrazol-1-Yl]Benzenesulfonamide-D4 is a deuterated analog of a pyrazole-based benzenesulfonamide, a compound class of significant interest in medicinal chemistry and analytical research. Its core value lies in its utility as a stable isotope-labeled internal standard, enabling precise quantification and metabolic studies in complex biological matrices. This high-purity compound is essential for researchers and developers in the pharmaceutical industry, particularly those focused on drug discovery, pharmacokinetics, and bioanalytical method development.

Application

• As a stable isotope-labeled internal standard for the accurate quantification of its non-deuterated counterpart in LC-MS/MS bioanalysis.
• For conducting metabolic stability studies and drug metabolism and pharmacokinetics (DMPK) research in preclinical development.
• Use in pharmaceutical impurity profiling and method validation to ensure specificity and accuracy.
• Application in mechanistic studies to trace the metabolic fate of lead compounds.
• As a critical reference material in contract research organizations (CROs) and academic research labs specializing in medicinal chemistry.
• For the development and calibration of diagnostic assays where high specificity is required.

Basic Information

Product Name	4-[5-(3-Fluoro-4-Methoxyphenyl)-3-(Difluoromethyl)-1H-Pyrazol-1-Yl]Benzenesulfonamide-D4
CAS No.	1794780-24-7
Molecular Formula	C17H10D4F3N3O3S
Molecular Weight	Contact for details
Synonyms	4-[5-(3-Fluoro-4-methoxyphenyl)-3-(difluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide-d4; 4-[5-(3-Fluoro-4-methoxyphenyl)-3-(difluoromethyl)pyrazol-1-yl]benzenesulfonamide-d4; Deuterated COX-2 Inhibitor Intermediate; Benzenesulfonamide, 4-[5-(3-fluoro-4-methoxyphenyl)-3-(difluoromethyl)-1H-pyrazol-1-yl]-, tetradeuterio-; Tetradeuterated Pyrazole Sulfonamide; Isotope Labeled Sulfonamide; [D4]-Labeled Sulfonamide Derivative
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical integrity. Each batch is characterized using advanced analytical techniques including NMR (¹H, ¹³C, ¹⁹F) and high-resolution mass spectrometry (HRMS) to confirm deuteration level and identity. Certificates of Analysis (COA) detailing isotopic purity (e.g., D4 ≥ 98%), chemical purity (by HPLC), and specific tests are provided with every shipment, supporting compliance with GLP and research standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake, which can affect stability and handling properties. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D4)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.