Description

5-[[3-[2-[Methyl[5-(Phenylmethoxy)-2-Pyridinyl]Amino]Ethoxy]Phenyl]Methyl]-2,4-Thiazolidinedione-D4 is a deuterated analog of a thiazolidinedione derivative, serving as a critical stable isotope-labeled internal standard for precise analytical quantification. This high-purity compound is essential for ensuring accuracy and reliability in mass spectrometry-based methods, particularly in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical service providers focused on drug discovery and bioanalysis.

Application

• Internal Standard for LC-MS/MS: Used as a deuterium-labeled internal standard for the accurate quantification of the parent drug in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Critical in studies investigating absorption, distribution, metabolism, and excretion (ADME) profiles to support regulatory filings.
• Bioanalytical Method Development and Validation: Enables the development of robust, sensitive, and specific analytical methods compliant with FDA and EMA guidelines.
• Clinical and Pre-clinical Trial Support: Provides reliable data for therapeutic drug monitoring and toxicokinetic assessments during drug development phases.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of related substances and degradation products in active pharmaceutical ingredient (API) batches.
• Metabolite Identification Studies: Facilitates the structural elucidation of drug metabolites by providing a stable isotopic reference point.

Basic Information

Product Name	5-[[3-[2-[Methyl[5-(Phenylmethoxy)-2-Pyridinyl]Amino]Ethoxy]Phenyl]Methyl]-2,4-Thiazolidinedione-D4
CAS No.	1794768-28-7
Molecular Formula	C25H21D4N3O3S
Molecular Weight	Contact for details
Synonyms	5-[[3-[2-[Methyl[5-(Benzyloxy)-2-pyridinyl]amino]ethoxy]phenyl]methyl]-2,4-thiazolidinedione-d4; Deuterated Thiazolidinedione Derivative; TZD-d4; Isotopically Labeled Internal Standard; 5-[[3-[2-[Methyl[5-(Phenylmethoxy)pyridin-2-yl]amino]ethoxy]phenyl]methyl]thiazolidine-2,4-dione-d4; (RS)-5-[[3-[2-[Methyl[5-(Benzyloxy)pyridin-2-yl]amino]ethoxy]phenyl]methyl]thiazolidine-2,4-dione-d4
EINECS	Contact for details

Quality Control

Every batch of our deuterated standards is produced and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity through advanced analytical techniques including NMR, HPLC, and high-resolution mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific data on purity, isotopic enrichment, and solvent content to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This compound is hygroscopic (moisture-sensitive). For long-term storage, consider storage under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.