Description

(4-Amino-1,2,3,6-tetrahydro-1-methyl-d3-2,6-dioxo-5-pyrimidinyl)-carbamic acid ethyl ester is a high-purity, deuterated pyrimidine derivative of significant importance in advanced pharmaceutical research and development. This compound serves as a critical stable isotope-labeled intermediate, enabling precise pharmacokinetic and metabolic studies. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel therapeutic agents, particularly for neurological and oncological targets.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of deuterated drug candidates, leveraging the kinetic isotope effect for improved metabolic stability.
• Metabolic Research: Used as an internal standard or tracer in mass spectrometry-based assays for accurate quantification and metabolic pathway analysis.
• Neurological Drug Development: Employed in research programs targeting adenosine receptor modulators and related central nervous system (CNS) active compounds.
• Oncology Research: Utilized in the development of novel pyrimidine-based chemotherapeutic agents and targeted therapies.
• Isotope Labeling Studies: Essential for conducting Absorption, Distribution, Metabolism, and Excretion (ADME) studies under regulatory guidelines (e.g., FDA, EMA).
• Chemical Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in analytical laboratories.

Basic Information

Product Name	(4-Amino-1,2,3,6-tetrahydro-1-methyl-d3-2,6-dioxo-5-pyrimidinyl)-carbamic acid ethyl ester
CAS No.	1794768-19-6
Molecular Formula	C9H10D3N3O4
Molecular Weight	230.23 g/mol
Synonyms	Ethyl (4-amino-1,2,3,6-tetrahydro-1-methyl-d3-2,6-dioxopyrimidin-5-yl)carbamate; 5-[(Ethoxycarbonyl)amino]-1-methyl-d3-1,2,3,6-tetrahydro-2,6-dioxopyrimidine; Deuteration-labeled SCH 58261 precursor; Deuterated Pyrimidine Carbamate; 1-Methyl-d3-5-ureidohydantoin ethyl ester (derivative); Adenosine A2A Receptor Antagonist Intermediate-d3; 5-Isocyanato-1-methyl-d3-uracil ethyl carbamate adduct
EINECS	Contact for details

Quality Control

Our (4-Amino-1,2,3,6-tetrahydro-1-methyl-d3-2,6-dioxo-5-pyrimidinyl)-carbamic acid ethyl ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (¹H, ¹³C) for structural and isotopic purity confirmation, HPLC for chemical purity assessment, and mass spectrometry for identity verification. We provide comprehensive Certificates of Analysis (COA) detailing purity, isotopic enrichment (D-content), and impurity profiles to support your regulatory submissions and research integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere (e.g., nitrogen or argon) to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.