Description

1-[[2'-(2,5-Dihydro-5-Oxo-1,2,4-Oxadiazol-3-Yl)[1,1'-Biphenyl]-4-Yl]Methyl]-2-Ethoxy-1H-Benzimidazole-7-Carboxylic-D5 Acid Methyl Ester is a high-purity, deuterated chemical intermediate of significant importance in advanced pharmaceutical research and development. Its core value lies in its role as a stable isotope-labeled analog, which is critical for conducting precise metabolism, pharmacokinetic (PK), and bioanalytical studies. This compound is essential for researchers and manufacturers in the pharmaceutical industry who require deuterium-labeled standards for drug discovery, development, and regulatory submission support. The CAS number for this compound is provided separately in the basic information below.

Application

• Deuterated Internal Standard for LC-MS/MS: Used as a critical quantitative standard in bioanalytical method development for accurate drug concentration measurement in biological matrices.
• Metabolite Identification and Tracing: Facilitates the study of drug metabolism pathways and the identification of metabolites in preclinical and clinical research.
• Pharmacokinetic (PK) and Pharmacodynamic (PD) Studies: Enables precise tracking of the parent drug's absorption, distribution, metabolism, and excretion (ADME) profile.
• Drug Discovery & Development: Serves as a key building block or reference material in the synthesis and analysis of novel therapeutic agents, particularly those containing a benzimidazole core.
• Stable Isotope Labeling: Employed in the synthesis of deuterated active pharmaceutical ingredients (APIs) for enhanced metabolic stability studies.
• Regulatory Submission Support: Provides essential data for regulatory filings (e.g., with the FDA, EMA) requiring validated bioanalytical methods with isotope-labeled standards.

Basic Information

Product Name	1-[[2'-(2,5-Dihydro-5-Oxo-1,2,4-Oxadiazol-3-Yl)[1,1'-Biphenyl]-4-Yl]Methyl]-2-Ethoxy-1H-Benzimidazole-7-Carboxylic-D5 Acid Methyl Ester
CAS No.	1794766-42-9
Molecular Formula	C27H19D5N4O5
Molecular Weight	~487.52 g/mol
Synonyms	Olmesartan Medoxomil Impurity D5; Olmesartan Medoxomil-d5; 1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic-d5 acid methyl ester; Deuterated Olmesartan Medoxomil Related Compound; Benzimidazole-d5 carboxylic acid ester derivative; (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylate-d5; Stable Isotope Labeled ARB Intermediate; Telmisartan Related Compound D5 (check specific structure).
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality control protocols to ensure the highest standards of isotopic purity and chemical purity. Each batch is characterized using advanced analytical techniques including NMR (¹H, ¹³C), High-Resolution Mass Spectrometry (HRMS), and HPLC. A comprehensive Certificate of Analysis (COA) is provided, detailing assay, isotopic enrichment (D5), and impurity profiles, supporting compliance with ICH Q2(R1) guidelines for analytical method validation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D5, MS)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.