Description

n-[3-Methyl-4-(2,2,2-Trifluoroethoxy)-2-Pyridinyl]Methyl Lansoprazole-D4 is a deuterated analog of a key pharmaceutical intermediate, specifically designed for advanced research and development applications. This high-purity compound serves as a critical internal standard and tracer in quantitative analytical methods, ensuring unparalleled accuracy in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers focused on proton pump inhibitor development and bioanalytical method validation.

Application

• Internal Standard for LC-MS/MS: Essential for the precise quantification of lansoprazole and related metabolites in complex biological matrices like plasma, serum, and tissue homogenates.
• Metabolic Pathway Tracing: Used in drug metabolism and pharmacokinetics (DMPK) studies to elucidate metabolic pathways and identify metabolites due to its isotopic label.
• Bioanalytical Method Development: A key component in developing and validating robust, GLP-compliant analytical methods for regulatory submissions.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradants in active pharmaceutical ingredient (API) batches.
• Stable Isotope Labeled Reference Material: Provides a reliable reference point in mass spectrometry, improving data accuracy and reproducibility in clinical and non-clinical trials.

Basic Information

Product Name	n-[3-Methyl-4-(2,2,2-Trifluoroethoxy)-2-Pyridinyl]Methyl Lansoprazole-D4
CAS No.	1794756-36-7
Molecular Formula	C16H14D4F3N3O2S
Molecular Weight	377.41 g/mol
Synonyms	Lansoprazole-d4 (specifically deuterated on the methylpyridinylmethyl group); 2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole-d4; AG-1749-d4; Prevacid-d4 (deuterated analog); (R)-(+)-Lansoprazole-d4; Lanzor-d4; Takepron-d4; Deuterated Lansoprazole Intermediate
EINECS	Contact for details

Quality Control

Every batch of n-[3-Methyl-4-(2,2,2-Trifluoroethoxy)-2-Pyridinyl]Methyl Lansoprazole-D4 is manufactured under controlled conditions and subjected to rigorous analytical testing to ensure it meets the stringent requirements for isotopic purity and chemical purity demanded by research applications. Our quality assurance protocols are designed to support GLP and cGMP environments. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (D%), chemical purity by HPLC, and identification data is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D%)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.